一种新型 VIM 型金属β-内酰胺酶变体 VIM-60，对日本铜绿假单胞菌临床分离株中第四代头孢菌素的水解活性增强。
A Novel VIM-Type Metallo-β-Lactamase Variant, VIM-60, with Increased Hydrolyzing Activity against Fourth-Generation Cephalosporins in Pseudomonas aeruginosa Clinical Isolates in Japan.
机构信息
Department of Microbiology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Department of Microbiology, Juntendo University Graduate School of Medicine, Tokyo, Japan
出版信息
Antimicrob Agents Chemother. 2019 May 24;63(6). doi: 10.1128/AAC.00124-19. Print 2019 Jun.
Abstract
A novel VIM-type metallo-β-lactamase variant, VIM-60, was identified in multidrug-resistant clinical isolates in Japan. Compared with VIM-2, VIM-60 had two amino acid substitutions (Arg228Leu and His252Arg) and higher catalytic activities against fourth-generation cephalosporins. The genetic context for was - on the chromosome.
摘要
在日本的多重耐药临床分离株中发现了一种新型的 VIM 型金属β-内酰胺酶变体 VIM-60。与 VIM-2 相比，VIM-60 有两个氨基酸取代（Arg228Leu 和 His252Arg），对第四代头孢菌素的催化活性更高。的遗传背景是在染色体上。
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