Anses, Fougères laboratory, BP 90203, F-35302 Fougères Cedex, France.
Vet Res. 2011 Mar 2;42(1):44. doi: 10.1186/1297-9716-42-44.
Antimicrobial resistance is of primary importance regarding public and animal health issues. Persistence and spread of resistant strains within a population contribute to the maintenance of a reservoir and lead to treatment failure. An experimental trial was carried out to study the horizontal transmission of a fluoroquinolone-resistant Escherichia coli strain from inoculated to naïve pigs. All naïve contact pigs had positive counts of fluoroquinolone-resistant E. coli after only two days of contact. Moreover, re-infections of inoculated pigs caused by newly contaminated animals were suspected. A maximum likelihood method, based on a susceptible-infectious-susceptible (SIS) model, was used to determine the transmission parameters. Two transmission levels were identified depending on the quantity of bacteria shed by infected individuals: (i) low-shedders with bacterial counts of resistant E. coli in the faeces between 5*10(3) and 10(6) CFU/g (βL = 0.41 [0.27; 0.62]), (ii) high shedders with bacterial counts above 10(6) CFU/g (βH = 0.98 [0.59; 1.62]). Hence, transmission between animals could be pivotal in explaining the persistence of resistant bacteria within pig herds.
抗微生物药物耐药性对公共卫生和动物健康问题至关重要。耐药菌株在人群中的持续存在和传播有助于维持储库，并导致治疗失败。进行了一项实验研究，以研究从接种猪向未接种猪传播氟喹诺酮耐药大肠杆菌菌株的水平传播。在接触仅两天后，所有未接种接触猪的粪便中都有氟喹诺酮耐药大肠杆菌的阳性计数。此外，怀疑新污染动物引起了接种猪的再感染。基于易感-感染-易感（SIS）模型的最大似然法用于确定传播参数。根据感染个体粪便中耐药大肠杆菌的数量，确定了两种传播水平：（i）低脱落者粪便中耐药大肠杆菌的细菌计数在 5*10(3)和 10(6)CFU/g 之间（βL = 0.41 [0.27; 0.62]），（ii）高脱落者粪便中细菌计数超过 10(6)CFU/g（βH = 0.98 [0.59; 1.62]）。因此，动物之间的传播可能是解释猪群中耐药菌持续存在的关键因素。
