Department of Biomedical Sciences, and Department of Medical Pharmacology and Physiology, Dalton Cardiovascular Research Center, University of Missouri-Columbia Columbia, MO, USA.
Front Physiol. 2010 Nov 29;1:156. doi: 10.3389/fphys.2010.00156. eCollection 2010.
In contrast to the "programmed" nature of apoptosis and autophagy, necrotic cell death has always been believed to be a random, uncontrolled process that leads to the "accidental" death of the cell. This dogma, however, is being challenged and the concept of necrosis also being "programmed" is gaining ground. In particular, mitochondria appear to play a pivotal role in the mediation of programmed necrosis. The purpose of this review, therefore, is to appraise the current concepts regarding the signaling mechanisms of programmed necrosis, with specific attention to the contribution of mitochondria to this process.
与细胞凋亡和自噬的“程序性”性质相反，坏死性细胞死亡一直被认为是一种随机的、不受控制的过程，导致细胞的“意外”死亡。然而，这种教条主义正受到挑战，坏死的概念也被认为是“程序性”的。特别是，线粒体似乎在程序性细胞坏死的调解中起着关键作用。因此，本文的目的是评估程序性细胞坏死的信号转导机制的当前概念，特别关注线粒体对此过程的贡献。
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