内生真菌尖孢镰刀菌的化学成分研究
Chemical constituents from endophytic fungus Fusarium oxysporum.
机构信息
School of Life Science, University of Science and Technology of China, PR China.
出版信息
Fitoterapia. 2011 Jul;82(5):777-81. doi: 10.1016/j.fitote.2011.04.002. Epub 2011 Apr 9.
A new oxysporidinone analogue (1) and a new 3-hydroxyl-2-piperidinone derivative (2), along with the known compounds (-)-4,6'-anhydrooxysporidinone (3), (+)-fusarinolic acid (4), gibepyrone D (5), beauvercin (6),cerevisterol (7), fusaruside (8), and (2S,2'R,3R,3'E,4E,8E)-1-O-D-glucopyranosyl-2-N-(2'-hydroxy-3'-octadecenoyl)-3-hydroxy-9-methyl-4,8-sphingadienine (9) were isolated from Fusarium oxysporum. Compounds 1-9 were evaluated for cytotoxicity using the MTT method against cancer cell lines, PC-3, PANC-1, and A549. Beauvericin showed cytotoxicity against PC-3, PANC-1, and A549 with IC(50) value of 49.5 ± 3.8, 47.2 ± 2.9, and 10.4 ± 1.6μM, respectively. Beauvericin also exhibited anti-bacterial activity towards methicillin-resistant Staphylococcus aureus (MIC=3.125 μg/mL) and Bacillus subtilis (MIC=3.125 μg/mL).
从尖孢镰刀菌（Fusarium oxysporum）中分离得到了一种新的氧杂孢菌素类似物（1）和一种新的 3-羟基-2-哌啶酮衍生物（2），以及已知化合物（-）-4,6'-脱水氧杂孢菌素（3）、（+）- Fusarinolic 酸（4）、吉贝吡酮 D（5）、 beauvercin（6）、cerevisterol（7）、fusaruside（8）和（2S,2'R,3R,3'E,4E,8E）-1-O-D-吡喃葡萄糖基-2-N-（2'-羟基-3'-十八烯酰基）-3-羟基-9-甲基-4,8- 鞘氨二烯碱（9）。采用 MTT 法测定了化合物 1-9 对前列腺癌细胞系 PC-3、胰腺癌细胞系 PANC-1 和肺腺癌细胞系 A549 的细胞毒性。Beauvercin 对 PC-3、PANC-1 和 A549 具有细胞毒性，IC50 值分别为 49.5±3.8、47.2±2.9 和 10.4±1.6μM。Beauvercin 对耐甲氧西林金黄色葡萄球菌（MIC=3.125μg/mL）和枯草芽孢杆菌（MIC=3.125μg/mL）也具有抗菌活性。
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