Gallego-Pinazo Roberto, Suelves-Cogollos Ana Marina, Dolz-Marco Rosa, Arevalo J Fernando, García-Delpech Salvador, Mullor J Luis, Díaz-Llopis Manuel
Department of Ophthalmology, Hospital Universitario La Fe, Valencia, Spain;
Clin Ophthalmol. 2011;5:613-7. doi: 10.2147/OPTH.S16833. Epub 2011 May 15.
The aim of this study was to compare the efficacy of spectral-domain optical coherence tomography (SD-OCT) and fluorescein angiography (FA) in the guidance of macular laser photocoagulation for diabetic macular edema.
This was a prospective interventional clinical comparative pilot study. Forty eyes from 24 consecutive patients with diabetic macular edema were allocated to receive laser photocoagulation guided by SD-OCT or FA. Best-corrected visual acuity (BCVA), central macular thickness, and retinal volume were assessed at baseline and two months after treatment.
Subjects treated using FA-guided laser improved BCVA from the logarithm of the minimum angle of resolution (logMAR) 0.52 ± 0.2 to 0.37 ± 0.2 (P < 0.001), and decreased mean central macular thickness from 397.25 ± 139.1 to 333.50 ± 105.7 μm (P < 0.001) and retinal volume from 12.61 ± 1.6 to 10.94 ± 1.4 mm(3) (P < 0.001). Subjects treated using SD-OCT guided laser had improved BCVA from 0.48 ± 0.2 to 0.33 ± 0.2 logMAR (P < 0.001), and decreased mean central macular thickness from 425.90 ± 149.6 to 353.4 ± 140 μm (P < 0.001) and retinal volume from 12.38 ± 2.1 to 11.53 ± 1.1 mm(3) (P < 0.001). No significant differences between the groups were found in two-month BCVA (P = 0.505), two-month central macular thickness (P = 0.660), or two-month retinal volume (P = 0.582).
The short-term results of this pilot study suggest that SD-OCT is a safe and effective technique and could be considered as a valid alternative to FA in the guidance of macular laser photocoagulation treatment for diabetic macular edema.
本研究的目的是比较光谱域光学相干断层扫描（SD-OCT）和荧光素血管造影（FA）在指导糖尿病性黄斑水肿的黄斑激光光凝治疗中的疗效。
这是一项前瞻性干预性临床对比试验研究。连续24例糖尿病性黄斑水肿患者的40只眼被分配接受SD-OCT或FA引导下的激光光凝治疗。在基线和治疗后两个月评估最佳矫正视力（BCVA）、黄斑中心厚度和视网膜体积。
接受FA引导激光治疗的受试者，其BCVA从最小分辨角对数（logMAR）0.52±0.2提高到0.37±0.2（P<0.001），黄斑中心平均厚度从397.25±139.1μm降至333.50±105.7μm（P<0.001），视网膜体积从12.61±1.6降至10.94±1.4mm³（P<0.001）。接受SD-OCT引导激光治疗的受试者，其BCVA从0.48±0.2提高到0.33±0.2 logMAR（P<0.001），黄斑中心平均厚度从425.90±149.6μm降至353.4±140μm（P<0.001），视网膜体积从12.38±2.1降至11.53±1.1mm³（P<0.001）。两组在治疗两个月时的BCVA（P=0.505）、黄斑中心厚度（P=0.660）或视网膜体积（P=0.582）方面均未发现显著差异。
这项初步研究的短期结果表明，SD-OCT是一种安全有效的技术，在指导糖尿病性黄斑水肿的黄斑激光光凝治疗中可被视为FA的有效替代方法。
