Farr T J, Harnett G B, Pietroboni G R, Bucens M R
Combined Microbiology Service, Queen Elizabeth II Medical Centre, Nedlands, Western Australia.
Epidemiol Infect. 1990 Dec;105(3):603-7. doi: 10.1017/s095026880004824x.
Sera from 141 infants aged 0-12 months were examined for IgG antibodies to HHV-6, HSV, CMV, VZV and EBV and for HHV-6 specific IgM. Following the decline in maternal antibody, antibody to HHV-6 was found to rise by 5-6 months and approached the level found in adults by 11-12 months. In contrast the antibody rates for the other herpesviruses were much slower to rise, especially in the case of CMV and EBV. HHV-6 IgM antibodies were detected mainly in age groups showing a rapid rise in antibody to HHV-6. HHV-6-IgM was not detected in 235 cord blood samples. The data suggest that HHV-6 infection is acquired horizontally, at a very early age in Western Australia.
检测了141名年龄在0至12个月的婴儿血清中的HHV-6、HSV、CMV、VZV和EBV的IgG抗体以及HHV-6特异性IgM。随着母体抗体水平下降，发现HHV-6抗体在5至6个月时上升，并在11至12个月时接近成人水平。相比之下，其他疱疹病毒的抗体上升速度要慢得多，尤其是CMV和EBV。HHV-6 IgM抗体主要在HHV-6抗体快速上升的年龄组中检测到。在235份脐带血样本中未检测到HHV-6-IgM。数据表明，在西澳大利亚州，HHV-6感染是在很小的时候通过水平传播获得的。
