Oral Biosciences, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Hong Kong, China.
Mycopathologia. 2011 Nov;172(5):389-95. doi: 10.1007/s11046-011-9444-4. Epub 2011 Jul 9.
Candida bloodstream infection has dramatically increased in the last decade due to the growing number of immunocompromised populations worldwide. In this study, we evaluated the antifungal susceptibility profiles and virulence attributes of Candida bloodstream isolates (CBIs) derived from Hong Kong and Finland, information which are vital for devising empirical clinical strategies. Susceptibility testing of a wide range of antifungals including fluconazole, itraconazole, voriconazole, ketoconazole, 5-fluorocytosine, amphotericin B and caspofungin was performed. Haemolytic activity and secretion of proteinase of CBIs were also examined. All CBIs derived from Hong Kong were susceptible to all the antifungals tested whilst some CBIs from Finland were resistant to azoles and caspofungin. C. albicans, C. glabrata and C. tropicalis showed higher haemolytic activity whereas C. parapsilosis and C. guilliermondii were non-haemolytic in general. Proteinase activity of the Finland C. albicans isolates was significantly higher than the Hong Kong isolates. Our data provide a glimpse of the possible evolutionary changes in pathogenic potential of Candida that may be occurring in different regions of the world. Therefore, continuous surveillance and availability of local data should be taken into consideration when treating candidemia patients.
由于全球免疫功能低下人群的数量不断增加，念珠菌血流感染在过去十年中显著增加。在这项研究中，我们评估了来自香港和芬兰的念珠菌血流分离株（CBI）的抗真菌药敏谱和毒力特征，这些信息对于制定经验性临床策略至关重要。对包括氟康唑、伊曲康唑、伏立康唑、酮康唑、5-氟胞嘧啶、两性霉素 B 和卡泊芬净在内的多种抗真菌药物进行了药敏试验。还检查了 CBI 的溶血活性和蛋白酶分泌。所有来自香港的 CBI 对所有测试的抗真菌药物均敏感，而来自芬兰的一些 CBI 对唑类药物和卡泊芬净耐药。C. albicans、C. glabrata 和 C. tropicalis 表现出较高的溶血活性，而 C. parapsilosis 和 C. guilliermondii 通常不溶血。芬兰 C. albicans 分离株的蛋白酶活性明显高于香港分离株。我们的数据提供了一个可能的线索，即念珠菌的致病潜力在世界不同地区可能正在发生的可能进化变化。因此，在治疗念珠菌血症患者时，应考虑到持续监测和获得当地数据的必要性。
