Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.
J Strength Cond Res. 2011 Sep;25(9):2552-8. doi: 10.1519/JSC.0b013e3181fb4809.
Clustering of cardiovascular risk factors may lead to endothelial dysfunction. Physical exercise is an important factor in prevention and treatment of endothelial dysfunction. We wanted to determine the time course of adaptation to a single bout of exercise at either high or moderate intensity upon endothelial function both before and after a 16-week fitness program in patients with metabolic syndrome. Twenty-eight patients with metabolic syndrome participated in the study and were randomized and stratified (according to age and sex) into an aerobic interval exercise training group (AIT, n = 11), a continuously moderate-intensity exercise training group (CME, n = 8) or to a control group (n = 9). Flow-mediated dilatation (FMD) was determined at baseline, immediately, 24, 48, and 72 hours after 1 bout of exercise and repeated after 16 weeks of exercise. In the untrained state, FMD improved from 5 to 11% (p = 0.003) immediately after a single bout of aerobic interval training (AIT), an effect lasting 72 hours postexercise. In comparison, continuous moderate exercise (CME) improved FMD immediately after a single bout of exercise from 5 to 8% (p = 0.02), an effect lasting 24 hours postexercise (group difference, p < 0.001). In the trained state, a single bout of AIT resulted in a 2% (p = 0.007) acute increase of FMD lasting 48 hours postexercise. The CME increased FMD by 3% (p < 0.01), an effect lasting 24 hours postexercise (group difference p = 0.0012). Blood glucose level decreased after 1 single bout of AIT in the untrained state (p < 0.05), and the effect lasted at least 72 hours postexercise (p < 0.01). Acute CME decreased blood glucose with normalization of the values 24 hours postexercise (p < 0.01). A single bout of exercise in the trained state reduced fasting blood glucose by 10% (p < 0.05) after both AIT and CME. Exercise training, especially high intensity, thus appears to be highly beneficial in reducing blood glucose and improving endothelial function.
心血管危险因素的聚集可能导致内皮功能障碍。体育锻炼是预防和治疗内皮功能障碍的重要因素。我们想确定在代谢综合征患者进行 16 周健身计划前后，单次高或中强度运动对内皮功能的适应时间过程。28 名代谢综合征患者参与了这项研究，并随机分为（根据年龄和性别）有氧间歇训练组（AIT，n=11）、持续中等强度运动训练组（CME，n=8）或对照组（n=9）。在基线、单次运动后即刻、24、48 和 72 小时以及运动 16 周后重复进行血流介导的扩张（FMD）测定。在未经训练的状态下，单次有氧间歇训练（AIT）后 FMD 从 5%提高到 11%（p=0.003），运动后 72 小时仍有效果。相比之下，连续中等强度运动（CME）后 FMD 从 5%提高到 8%（p=0.02），运动后 24 小时仍有效果（组间差异，p<0.001）。在训练状态下，单次 AIT 导致 FMD 急性增加 2%（p=0.007），持续 48 小时。CME 使 FMD 增加 3%（p<0.01），运动后 24 小时仍有效果（组间差异，p=0.0012）。在未经训练的状态下，单次 AIT 后血糖水平降低（p<0.05），至少在运动后 72 小时（p<0.01）仍有效果。急性 CME 使血糖降低，运动后 24 小时恢复正常（p<0.01）。在训练状态下，单次运动后，AIT 和 CME 均可使空腹血糖降低 10%（p<0.05）。运动训练，尤其是高强度运动，似乎对降低血糖和改善内皮功能非常有益。
