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在疫情调查中,质粒图谱分型可用于细分鼠伤寒沙门氏菌的噬菌体49型。

Plasmid profile typing can be used to subdivide phage-type 49 of Salmonella typhimurium in outbreak investigations.

作者信息

Threlfall E J, Frost J A, Ward L R, Rowe B

机构信息

Division of Enteric Pathogens, Central Public Health Laboratory, London.

出版信息

Epidemiol Infect. 1990 Apr;104(2):243-51. doi: 10.1017/s0950268800059410.

Abstract

Plasmid profile typing has been used to subdivide phage-type 49 of Salmonella typhimurium, the most common phage type in humans in England and Wales since 1985. Twenty profile patterns have been identified in 350 strains examined. Four profile patterns have been identified in 143 isolates from patients infected in 33 epidemiologically unrelated incidents and two patterns have predominated, ST49:62 and ST49:62, 1. These patterns were also common amongst S. typhimurium phage-type 49 isolated from cattle and poultry; however ST49:62 was more common in bovines whereas ST49:62, 1 predominated in poultry. S. typhimurium phage-type 49 with a different profile pattern, ST49:62, 3, was responsible for a large outbreak in London in 1988 which was traced to mayonnaise made from eggs supplied by one producer. Plasmid profile typing can now be regarded as a method of supplementing phage typing in investigating outbreaks caused by this organism.

摘要

质粒图谱分型已被用于对鼠伤寒沙门氏菌噬菌体49型进行细分,自1985年以来,该噬菌体类型是英格兰和威尔士人类中最常见的噬菌体类型。在所检测的350株菌株中已鉴定出20种图谱模式。在来自33起流行病学上无关联事件中感染患者的143株分离株中鉴定出4种图谱模式,其中两种模式占主导地位,即ST49:62和ST49:62,1。这些模式在从牛和家禽中分离出的鼠伤寒沙门氏菌噬菌体49型中也很常见;然而,ST49:62在牛中更常见,而ST49:62,1在家禽中占主导地位。具有不同图谱模式ST49:62,3的鼠伤寒沙门氏菌噬菌体49型在1988年伦敦引发了一次大规模疫情,该疫情追溯到由一家生产商供应的鸡蛋制成的蛋黄酱。现在,质粒图谱分型可被视为在调查由该生物体引起的疫情时补充噬菌体分型的一种方法。

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