Department of Radiology and Medical Imaging, Center of Imaging for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, California, USA.
Mov Disord. 2012 Jan;27(1):90-7. doi: 10.1002/mds.23917. Epub 2011 Aug 17.
This study tested the hypothesis that diffusion tensor imaging can detect alteration in microscopic integrity of white matter and basal ganglia regions known to be involved in Parkinson's disease (PD) pathology. It was also hypothesized that there is an association between diffusion abnormality and PD severity and subtype. Diffusion tensor imaging at 4 Tesla was obtained in 12 PD and 20 control subjects, and measures of fractional anisotropy and mean diffusivity were evaluated using both region-of-interest and voxel-based methods. Movement deficits and subtypes in PD subjects were assessed using the Motor Subscale (Part III) of the Unified Parkinson's Disease Rating Scale. Reduced fractional anisotropy (P < .05, corrected) was found in PD subjects in regions related to the precentral gyrus, substantia nigra, putamen, posterior striatum, frontal lobe, and the supplementary motor areas. Reduced fractional anisotropy in the substantia nigra correlated (P < .05, corrected) with the increased rating scale motor scores. Significant spatial correlations between fractional anisotropy alterations in the putamen and other PD-affected regions were also found in the context of PD subtypes index analysis. Our data suggest that microstructural alterations detected with diffusion tensor might serve as a potential biomarker for PD.
本研究旨在验证扩散张量成像（DTI）是否可检测已知与帕金森病（PD）病理学相关的白质和基底节区微观完整性改变的假说。研究还假设扩散异常与 PD 严重程度和亚型之间存在关联。在 12 名 PD 患者和 20 名对照组受试者中进行了 4T 磁共振弥散张量成像，使用基于感兴趣区和体素的方法评估各向异性分数（FA）和平均弥散系数（MD）的测量值。采用统一帕金森病评定量表运动部分（第 III 部分）评估 PD 患者的运动缺陷和亚型。结果发现，PD 患者与中央前回、黑质、壳核、后纹状体、额叶和辅助运动区相关的区域 FA 值降低（P <.05，校正）。黑质 FA 值降低与运动评分量表的增高评分呈正相关（P <.05，校正）。在 PD 亚型指数分析中，还发现了壳核和其他受 PD 影响区域的 FA 值改变之间存在显著的空间相关性。我们的数据表明，扩散张量检测到的微观结构改变可能成为 PD 的潜在生物标志物。
