Associated Regional and University Pathologists Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84108, USA.
Emerg Infect Dis. 2011 Sep;17(9):1692-700. doi: 10.3201/eid1709.101667.
Members of the Mycobacterium chelonae-abscessus complex represent Mycobacterium species that cause invasive infections in immunocompetent and immunocompromised hosts. We report the detection of a new pathogen that had been misidentified as M. chelonae with an atypical antimicrobial drug susceptibility profile. The discovery prompted a multicenter investigation of 26 patients. Almost all patients were from the northeastern United States, and most had underlying sinus or pulmonary disease. Infected patients had clinical features similar to those with M. abscessus infections. Taxonomically, the new pathogen shared molecular identity with members of the M. chelonae-abscessus complex. Multilocus DNA target sequencing, DNA-DNA hybridization, and deep multilocus sequencing (43 full-length genes) support a new taxon for these microorganisms. Because most isolates originated in Pennsylvania, we propose the name M. franklinii sp. nov. This investigation underscores the need for accurate identification of Mycobacterium spp. to detect new pathogens implicated in human disease.
龟分枝杆菌-脓肿分枝杆菌复合体的成员代表了引起免疫功能正常和免疫功能低下宿主侵袭性感染的分枝杆菌种。我们报告了一种新病原体的检测，该病原体曾被错误鉴定为具有非典型抗微生物药物敏感性谱的龟分枝杆菌。这一发现促使我们对 26 名患者进行了多中心调查。几乎所有的患者都来自美国东北部，大多数患者都有鼻窦或肺部疾病。感染患者的临床特征与脓肿分枝杆菌感染相似。从分类学上看，新病原体与龟分枝杆菌-脓肿分枝杆菌复合体的成员具有分子同一性。多位点 DNA 靶标测序、DNA-DNA 杂交和深度多位点测序（43 个全长基因）支持这些微生物的一个新分类群。由于大多数分离株源自宾夕法尼亚州，我们提议将这些微生物命名为弗兰克利分枝杆菌新种。本研究强调了准确鉴定分枝杆菌种以检测新的与人类疾病相关的病原体的必要性。
