Song Young Chan, Hahn Hyung Jin, Kim Ji Young, Ko Jong Hyun, Lee Yang Won, Choe Yong Beom, Ahn Kyu Joong
Department of Dermatology, Konkuk University School of Medicine, Seoul, Korea.
Ann Dermatol. 2011 Aug;23(3):321-8. doi: 10.5021/ad.2011.23.3.321. Epub 2011 Aug 6.
Although acne is a common follicular inflammatory dermatosis, studies of the relationship between Malassezia yeasts and acne have rarely been conducted.
We sought to identify Malassezia yeasts from acne patients and establish a relationship between specific types of species of Malassezia and acne.
Sixty acne patients were enrolled. Each strain obtained was identified as one of eleven species by 26S rDNA PCR-RFLP. We then compared these data with those of age- and sex-matched healthy subjects.
Growth of Malassezia was evident in fewer patients with acne (50%) in comparison to controls (70.6%). M. restricta was dominant in patients with acne (23.9%), whereas M. globosa was most common (26.7%) in healthy controls. In the patients group, the rate was the highest (71.7%) in the twenties and, in terms of body site, the rate was the highest (60%) in the chest. In the control group, the rate was the highest (75.0%) in the thirties and in the forehead (85.0%).
The detection rate of Malassezia yeasts was conspicuously low in the acne patients group. Statistically significant differences were observed between the patient and the control groups in the twenties and thirties, and in terms of body site, in the forehead and chest.
尽管痤疮是一种常见的毛囊炎性皮肤病，但关于马拉色菌与痤疮之间关系的研究却很少进行。
我们试图从痤疮患者中鉴定出马拉色菌，并确定特定种类的马拉色菌与痤疮之间的关系。
招募了60名痤疮患者。通过26S rDNA PCR-RFLP将获得的每一株菌株鉴定为11种之一。然后我们将这些数据与年龄和性别匹配的健康受试者的数据进行比较。
与对照组（70.6%）相比，痤疮患者中马拉色菌生长明显的患者较少（50%）。局限马拉色菌在痤疮患者中占主导地位（23.9%），而球形马拉色菌在健康对照组中最为常见（26.7%）。在患者组中，二十多岁的患者发生率最高（71.7%），就身体部位而言，胸部的发生率最高（60%）。在对照组中，三十多岁的患者发生率最高（75.0%），在前额的发生率最高（85.0%）。
痤疮患者组中马拉色菌的检出率明显较低。在二十多岁和三十多岁的患者组之间，以及就身体部位而言，在前额和胸部，患者组与对照组之间观察到统计学上的显著差异。
