Orygen Youth Health Research Centre, Locked Bag 10, Parkville, Vic 3052, Australia.
Soc Cogn Affect Neurosci. 2012 Jan;7(1):23-34. doi: 10.1093/scan/nsr049. Epub 2011 Sep 14.
The way that parents express their emotions during interactions with their adolescent children is important for adolescent adjustment, and predicts adolescent emotional problems such as depression. In the current study, we assessed whether adolescent depressive symptoms were associated with neural activity during exposure to their mother's affective behavior. Thirty adolescents (18 females, mean age 17.35, s.d. 0.43) participated in an fMRI task that used digitized video segments of their own mother's, as well as an unfamiliar mother's affective behavior as stimuli. Exposure to one's own (compared to an unfamiliar) mother's positive (compared to neutral) behavior was associated with activation in the anterior and posterior cingulate, precuneus and ventrolateral prefrontal cortex. In contrast, exposure to positive behavior across own and an unfamiliar mother (controlling for neutral behavior) was associated with superior temporal sulcus, occipital pole, amygdala and striatum activity. Adolescent depressive symptoms were associated with reduced rostral anterior cingulate activity during exposure to one's own (compared to an unfamiliar) mother's positive behavior, and reduced striatal activity during exposure to positive behavior in general. This study represents an important step in furthering our understanding of the neural basis of affective processing in adolescents. Further, the results support a disruption of reward function in depression.
父母在与青少年子女互动时表达情绪的方式对青少年的适应很重要，并可预测青少年的情绪问题，如抑郁。在本研究中，我们评估了青少年的抑郁症状是否与他们在接触母亲的情感行为时的神经活动有关。 30 名青少年（18 名女性，平均年龄 17.35，s.d. 0.43）参与了一项 fMRI 任务，该任务使用他们自己母亲以及陌生母亲的情感行为的数字化视频片段作为刺激。与接触自己的（相比陌生的）母亲的积极（相比中性）行为相比，接触自己的（相比陌生的）母亲的积极（相比中性）行为与前扣带回、楔前叶和腹外侧前额叶皮层的激活有关。相比之下，接触自己和陌生母亲的积极行为（控制中性行为）与颞上沟、枕极、杏仁核和纹状体的活动有关。青少年的抑郁症状与接触自己（相比陌生的）母亲的积极行为时前扣带回的活动减少有关，与接触积极行为时纹状体的活动减少有关。这项研究是进一步了解青少年情感处理的神经基础的重要一步。此外，结果支持抑郁时奖励功能的中断。
