Centro de Excelencia en Salud Cardiovascular para el Cono Sur (CESCAS/SACECH), Instituto de Efectividad Clínica y Sanitaria, Buenos Aires, Argentina; Facultad de Ciencias Médicas, Escuela de Nutrición, Universidad Nacional de Córdoba, Córdoba, Argentina.
J Clin Hypertens (Greenwich). 2014 Dec;16(12):907-13. doi: 10.1111/jch.12431. Epub 2014 Nov 6.
The purpose of this study was to conduct a systematic review on the association of food patterns (FPs) and endothelial biomarkers. An electronic literature search from 1990 to 2012 was conducted and reference lists and experts were consulted. Studies without dietary intervention and without language restrictions were considered. Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were employed. Methodological quality was assessed by Strengthening the Reporting of Observational Studies in Epidemiology guidelines. A total of 546 references were identified, of which 8 were finally included. Several FPs were identified. Healthy FPs (abundant in fruits and vegetables) had a beneficial impact on endothelial function as estimated by circulating levels of biomarkers such as C-reactive protein, soluble intercellular adhesion molecule 1, soluble vascular adhesion molecule 1, and E-selectin molecules. Westernized patterns (higher intakes of processed meats, sweets, fried foods, and refined grains) were positively associated with inflammation molecules and atherogenic promoters. The study of FPs in relation to endothelial function contributes to the development of dietary recommendations for improved cardiovascular health and therefore a better lifestyle.
本研究旨在对食物模式（FPs）与内皮生物标志物之间的关联进行系统综述。从 1990 年到 2012 年进行了电子文献检索，并查阅了参考文献列表和专家意见。考虑了没有饮食干预且没有语言限制的研究。采用了系统评价和荟萃分析报告的首选项目。采用流行病学观察研究报告强化标准评估方法学质量。共确定了 546 篇参考文献，其中最终纳入了 8 篇。确定了几种 FPs。健康的 FPs（富含水果和蔬菜）对内皮功能具有有益影响，这可以通过循环生物标志物（如 C 反应蛋白、可溶性细胞间黏附分子 1、可溶性血管细胞黏附分子 1 和 E-选择素分子）的水平来估计。西化模式（加工肉类、甜食、油炸食品和精制谷物的摄入量较高）与炎症分子和动脉粥样硬化促进剂呈正相关。研究 FPs 与内皮功能之间的关系有助于制定改善心血管健康的饮食建议，从而改善生活方式。
