刺芹对链脲佐菌素诱导的糖尿病大鼠的降血脂活性
Hypolipidemic Activity of Eryngium carlinae on Streptozotocin-Induced Diabetic Rats.
作者信息
Noriega-Cisneros Ruth, Ortiz-Ávila Omar, Esquivel-Gutiérrez Edgar, Clemente-Guerrero Mónica, Manzo-Avalos Salvador, Salgado-Garciglia Rafael, Cortés-Rojo Christian, Boldogh Istvan, Saavedra-Molina Alfredo
机构信息
Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, 58030 Morelia, Michoacán, Mexico.
出版信息
Biochem Res Int. 2012;2012:603501. doi: 10.1155/2012/603501. Epub 2011 Nov 24.
Abstract
Diabetes mellitus (DM) is a significant risk factor for the development of cardiovascular complications. This study was undertaken to investigate the effect of chronic administration of ethanolic extract of Eryngium carlinae on glucose, creatinine, uric acid, total cholesterol, and triglycerides levels in serum of streptozotocin- (STZ-) induced diabetic rats. Triglycerides, total cholesterol, and uric acid levels increased in serum from diabetic rats. The treatment with E. carlinae prevented these changes. The administration of E. carlinae extract reduced the levels of creatinine, uric acid, total cholesterol, and triglycerides. Thus administration of E. carlinae is able to reduce hyperlipidemia related to the cardiovascular risk in diabetes mellitus.
摘要
糖尿病（DM）是心血管并发症发生的重要危险因素。本研究旨在探讨长期给予刺芹乙醇提取物对链脲佐菌素（STZ）诱导的糖尿病大鼠血清中葡萄糖、肌酐、尿酸、总胆固醇和甘油三酯水平的影响。糖尿病大鼠血清中的甘油三酯、总胆固醇和尿酸水平升高。刺芹治疗可预防这些变化。刺芹提取物的给药降低了肌酐、尿酸、总胆固醇和甘油三酯的水平。因此，给予刺芹能够降低糖尿病中与心血管风险相关的高脂血症。
相似文献
1
Hypolipidemic Activity of Eryngium carlinae on Streptozotocin-Induced Diabetic Rats.刺芹对链脲佐菌素诱导的糖尿病大鼠的降血脂活性
Biochem Res Int. 2012;2012:603501. doi: 10.1155/2012/603501. Epub 2011 Nov 24.
2
Ethanol Extract Corrects Lipid Abnormalities in Wistar Rats with Experimental Diabetes.乙醇提取物纠正实验性糖尿病 Wistar 大鼠的脂质异常。
J Med Food. 2020 Aug;23(8):827-833. doi: 10.1089/jmf.2019.0189. Epub 2019 Dec 12.
3
An Ethyl Acetate Extract of Inflorescences Attenuates Oxidative Stress and Inflammation in the Liver of Streptozotocin-Induced Diabetic Rats.花序的乙酸乙酯提取物可减轻链脲佐菌素诱导的糖尿病大鼠肝脏中的氧化应激和炎症。
Antioxidants (Basel). 2023 Jun 7;12(6):1235. doi: 10.3390/antiox12061235.
4
Protective Effect of the Hexanic Extract of Inflorescences In Vitro, in Yeast, and in Streptozotocin-Induced Diabetic Male Rats.花序正己烷提取物在体外、酵母及链脲佐菌素诱导的糖尿病雄性大鼠中的保护作用
Antioxidants (Basel). 2019 Mar 26;8(3):73. doi: 10.3390/antiox8030073.
5
Hypolipidemic activity of 18beta-glycyrrhetinic acid on streptozotocin-induced diabetic rats.18β-甘草次酸对链脲佐菌素诱导的糖尿病大鼠的降血脂活性
Eur J Pharmacol. 2009 Jun 10;612(1-3):93-7. doi: 10.1016/j.ejphar.2009.04.003. Epub 2009 Apr 8.
6
Antidiabetic and antioxidant effects of Annona muricata (Annonaceae), aqueous extract on streptozotocin-induced diabetic rats.紫玉盘（番荔枝科）水提物对链脲佐菌素诱导的糖尿病大鼠的降血糖和抗氧化作用。
J Ethnopharmacol. 2014 Feb 3;151(2):784-90. doi: 10.1016/j.jep.2013.09.021. Epub 2013 Sep 25.
7
Antidiabetic and antihyperlipidemic effects of ethanolic Ferula assa-foetida oleo-gum-resin extract in streptozotocin-induced diabetic wistar rats.水飞蓟宾对糖尿病大鼠血糖、血脂的影响。
Biomed Pharmacother. 2019 Feb;110:197-202. doi: 10.1016/j.biopha.2018.10.152. Epub 2018 Nov 22.
8
Antihyperglycemic and antihyperlipidemic effects of hydroalcoholic extract of Securigera securidaca seeds in streptozotocin-induced diabetic rats.紫雀花种子水醇提取物对链脲佐菌素诱导的糖尿病大鼠的降血糖和降血脂作用
Adv Biomed Res. 2015 Jan 30;4:33. doi: 10.4103/2277-9175.150427. eCollection 2015.
9
Effect of vanadyl sulfate on the status of lipid parameters and on stomach and spleen tissues of streptozotocin-induced diabetic rats.硫酸氧钒对链脲佐菌素诱导的糖尿病大鼠脂质参数状态以及胃和脾脏组织的影响。
Pharmacol Res. 2006 Mar;53(3):271-7. doi: 10.1016/j.phrs.2005.12.004. Epub 2006 Jan 20.
10
Antioxidant and triglyceride-lowering effects of vitamin E associated with the prevention of abnormalities in the reactivity and morphology of aorta from streptozotocin-diabetic rats. Antioxidants in Diabetes-Induced Complications (ADIC) Study Group.维生素E的抗氧化和降甘油三酯作用与预防链脲佐菌素诱导的糖尿病大鼠主动脉反应性和形态异常相关。糖尿病并发症抗氧化剂（ADIC）研究组。
Metabolism. 1997 Aug;46(8):872-9. doi: 10.1016/s0026-0495(97)90072-x.
引用本文的文献
1
Antioxidant Effect of the Ethyl Acetate Extract of on Kidney Mitochondria of Streptozotocin-Induced Diabetic Rats.链脲佐菌素诱导的糖尿病大鼠肾脏线粒体上[提取物名称]乙酸乙酯提取物的抗氧化作用 。（你原文中“of”后面似乎缺失了提取物名称等关键信息）
Plants (Basel). 2023 Sep 7;12(18):3196. doi: 10.3390/plants12183196.
2
An Ethyl Acetate Extract of Inflorescences Attenuates Oxidative Stress and Inflammation in the Liver of Streptozotocin-Induced Diabetic Rats.花序的乙酸乙酯提取物可减轻链脲佐菌素诱导的糖尿病大鼠肝脏中的氧化应激和炎症。
Antioxidants (Basel). 2023 Jun 7;12(6):1235. doi: 10.3390/antiox12061235.
3
Ethnobotany, Biological Activities and Phytochemical Compounds of Some Species of the Genus (Apiaceae), from the Central-Western Region of Mexico.墨西哥中西部地区一些独活属（伞形科）植物的民族植物学、生物活性和植物化学化合物。
Molecules. 2023 May 15;28(10):4094. doi: 10.3390/molecules28104094.
4
Species as a Potential Ally for Treating Metabolic Syndrome and Diabetes.物种作为治疗代谢综合征和糖尿病的潜在盟友。
Front Nutr. 2022 May 20;9:878306. doi: 10.3389/fnut.2022.878306. eCollection 2022.
5
Antilipidemic and Hepatoprotective Effects of Ethanol Extract of in Streptozotocin Diabetic Rats.在链脲佐菌素诱导的糖尿病大鼠中， 的乙醇提取物具有抗脂和保肝作用。
Nutrients. 2022 May 6;14(9):1946. doi: 10.3390/nu14091946.
6
Phytochemical Study of F. Delaroche and the Inhibitory Capacity of Its Main Compounds on Two Glucose-Producing Pathway Enzymes.德氏木蓝的植物化学研究及其主要化合物对两种葡萄糖生成途径酶的抑制能力
Plants (Basel). 2022 Apr 5;11(7):992. doi: 10.3390/plants11070992.
7
In Vitro and In Vivo Antidiabetic Potential of Monoterpenoids: An Update.单萜类化合物的体外和体内抗糖尿病潜力：更新。
Molecules. 2021 Dec 29;27(1):182. doi: 10.3390/molecules27010182.
8
Protective Effect of the Hexanic Extract of Inflorescences In Vitro, in Yeast, and in Streptozotocin-Induced Diabetic Male Rats.花序正己烷提取物在体外、酵母及链脲佐菌素诱导的糖尿病雄性大鼠中的保护作用
Antioxidants (Basel). 2019 Mar 26;8(3):73. doi: 10.3390/antiox8030073.
9
Bioactivity of Methanolic Extracts from (Schltdl.) Schiede ex Standl., L., DC., F. Delaroche, and (Roxb.) Benth. Used in Traditional Medicine in Mexico.墨西哥传统医学中使用的裂榄（学名：Bursera fagaroides (Schltdl.) Schiede ex Standl.）、微白黄檀（学名：Dalbergia albida L.）、平卧番荔枝（学名：Annona mexicana DC.）、墨西哥天芥菜（学名：Heliotropium mexicanum F. Delaroche）及刺果苏木（学名：Caesalpinia bonduc (Roxb.) Benth.）甲醇提取物的生物活性
Evid Based Complement Alternat Med. 2018 Feb 28;2018:3610364. doi: 10.1155/2018/3610364. eCollection 2018.
10
The Hypocholesterolemic Effects of F. Delaroche Are Mediated by the Involvement of the Intestinal Transporters ABCG5 and ABCG8.德氏木犀榄的降胆固醇作用是由肠道转运蛋白ABCG5和ABCG8介导的。
Evid Based Complement Alternat Med. 2017;2017:3176232. doi: 10.1155/2017/3176232. Epub 2017 Dec 14.
本文引用的文献
1
Antidiabetic Activity of Vinca rosea Extracts in Alloxan-Induced Diabetic Rats.长春花提取物对四氧嘧啶诱导糖尿病大鼠的降血糖活性。
Int J Endocrinol. 2010;2010:841090. doi: 10.1155/2010/841090. Epub 2010 Jun 22.
2
Antidiabetic, antihyperlipidemic and antioxidant activities of methanolic extract of Amaranthus viridis Linn in alloxan induced diabetic rats.绿穗苋甲醇提取物对四氧嘧啶诱导的糖尿病大鼠的抗糖尿病、抗高血脂和抗氧化活性
Exp Toxicol Pathol. 2012 Jan;64(1-2):75-9. doi: 10.1016/j.etp.2010.06.009. Epub 2010 Jul 18.
3
[HbA1c, standardization and expression of results].
Endocrinol Nutr. 2010 May;57(5):177-81. doi: 10.1016/j.endonu.2010.02.010. Epub 2010 Apr 28.
4
Antioxidant potential of aqueous extract of Phyllanthus amarus in rats.叶下珠水提物的抗氧化潜力。
Indian J Pharmacol. 2009 Apr;41(2):64-7. doi: 10.4103/0253-7613.51342.
5
Lipid abnormalities in streptozotocin-diabetes: Amelioration by Morus indica L. cv Suguna leaves.链脲佐菌素诱导糖尿病中的脂质异常：桑（Morus indica L. cv Suguna）叶的改善作用。
Int J Diabetes Dev Ctries. 2009 Jul;29(3):123-8. doi: 10.4103/0973-3930.54289.
6
Serum uric acid levels predict the development of albuminuria over 6 years in patients with type 1 diabetes: findings from the Coronary Artery Calcification in Type 1 Diabetes study.血清尿酸水平可预测 1 型糖尿病患者 6 年内白蛋白尿的发展：来自 1 型糖尿病冠状动脉钙化研究的结果。
Nephrol Dial Transplant. 2010 Jun;25(6):1865-9. doi: 10.1093/ndt/gfp740. Epub 2010 Jan 11.
7
Antidiabetic activity of ethanolic extract of Zaleya decandra in alloxan-induced diabetic rats.千层塔正丁醇提取物对四氧嘧啶诱导糖尿病大鼠的降血糖作用。
Appl Biochem Biotechnol. 2010 Oct;162(4):1153-9. doi: 10.1007/s12010-009-8871-x. Epub 2009 Dec 3.
8
Anti-hyperglycaemic potential of Psidium guajava raw fruit peel.番石榴生果皮的抗高血糖潜力
Indian J Med Res. 2009 May;129(5):561-5.
9
Liver-specific loss of lipolysis-stimulated lipoprotein receptor triggers systemic hyperlipidemia in mice.肝脏特异性缺失脂解刺激脂蛋白受体引发小鼠全身性高脂血症。
Diabetes. 2009 May;58(5):1040-9. doi: 10.2337/db08-1184. Epub 2009 Feb 2.
10
Protective effects of morroniside isolated from Corni Fructus against renal damage in streptozotocin-induced diabetic rats.山茱萸中分离出的莫诺苷对链脲佐菌素诱导的糖尿病大鼠肾损伤的保护作用。
Biol Pharm Bull. 2008 Jul;31(7):1422-8. doi: 10.1248/bpb.31.1422.
Zotero 插件