Bello Ibrahim O, Salo Tuula, Dayan Dan, Tervahauta Elisa, Almangoush Alhadi, Schnaiderman-Shapiro Anna, Barshack Iris, Leivo Ilmo, Vered Marilena
Department of Diagnostics and Oral Medicine, Institute of Dentistry, University of Oulu, Oulu, Finland.
Head Neck Pathol. 2012 Jun;6(2):224-31. doi: 10.1007/s12105-011-0316-5. Epub 2012 Jan 7.
Salivary gland tumors (SGTs) of epithelial origin are relatively rare, and worldwide reports show considerable variations in their epidemiology. The aim of this study was to examine, for the first time, the records of SGTs from two very distant geographical locations, Finland (two medical centers) and Israel (one medical center) between 1999 and 2008, based exclusively on the 2005 WHO classification of head and neck tumors, and to compare those data to the other available (single-center) studies that used the same classification. A total of 2,218 benign and malignant tumors diagnosed in the three centers were analyzed. Differences in classification of the tumors were found between the two geographical locations as well as between the two centers from Finland. There was a higher ratio of benign-to-malignant SGTs in the Finnish centers (5.4:1 and 7:1) compared to the Israeli center (2:1), a higher frequency of tumors of minor salivary glands in the Israeli center (34%) than in the Finnish centers (4 and 11%), and a higher frequency of malignant SGTs in the minor salivary glands in Israel (64.5%) than in Finland (10.9 and 27%). The diversity of these multicenter data are compatible with reports from different parts of the world. We conclude that conducting epidemiologic surveys based on the latest WHO classification provides clinicopathologic correlations on SGTs that seem to be characteristic even in small geographical regions.
上皮源性涎腺肿瘤（SGTs）相对罕见，全球范围内的报告显示其流行病学存在显著差异。本研究旨在首次专门依据2005年世界卫生组织头颈部肿瘤分类，对1999年至2008年间来自两个地理位置相距甚远的地区——芬兰（两个医疗中心）和以色列（一个医疗中心）的SGTs记录进行审查，并将这些数据与其他使用相同分类的单中心研究数据进行比较。对三个中心诊断出的总共2218例良性和恶性肿瘤进行了分析。发现两个地理位置之间以及芬兰的两个中心之间在肿瘤分类上存在差异。与以色列中心（2:1）相比，芬兰中心的良性SGT与恶性SGT的比例更高（分别为5.4:1和7:1）；以色列中心小涎腺肿瘤的发生率（34%）高于芬兰中心（分别为4%和11%）；以色列小涎腺恶性SGT的发生率（64.5%）高于芬兰（分别为10.9%和27%）。这些多中心数据的多样性与世界不同地区的报告相符。我们得出结论，基于世界卫生组织最新分类进行流行病学调查可提供SGTs的临床病理相关性，即使在小地理区域内这些相关性似乎也具有特征性。
