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Small molecule inhibitors of arginyltransferase regulate arginylation-dependent protein degradation, cell motility, and angiogenesis.精氨酸转移酶小分子抑制剂调节依赖精氨酸化的蛋白质降解、细胞迁移和血管生成。
Biochem Pharmacol. 2012 Apr 1;83(7):866-73. doi: 10.1016/j.bcp.2012.01.012. Epub 2012 Jan 18.
2
High-Throughput Arginylation Assay in Microplate Format.微孔板形式的高通量精氨酰化分析
Methods Mol Biol. 2023;2620:119-122. doi: 10.1007/978-1-0716-2942-0_16.
3
High-Throughput Arginylation Assay in Microplate Format.微孔板形式的高通量精氨酰化分析
Methods Mol Biol. 2015;1337:79-82. doi: 10.1007/978-1-4939-2935-1_11.
4
Ate1-mediated posttranslational arginylation affects substrate adhesion and cell migration in Dictyostelium discoideum.Ate1 介导的翻译后精氨酸化影响盘基网柄菌中底物黏附和细胞迁移。
Mol Biol Cell. 2019 Feb 15;30(4):453-466. doi: 10.1091/mbc.E18-02-0132. Epub 2018 Dec 26.
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Post-translational protein arginylation in the normal nervous system and in neurodegeneration.正常神经系统和神经退行性变中的蛋白质翻译后精氨酰化
J Neurochem. 2016 Aug;138(4):506-17. doi: 10.1111/jnc.13708. Epub 2016 Jul 5.
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Targeting human arginyltransferase and post-translational protein arginylation: a pharmacophore-based multilayer screening and molecular dynamics approach to discover novel inhibitors with therapeutic promise.靶向人类精氨酰转移酶和翻译后蛋白质精氨酰化：一种基于药效团的多层筛选和分子动力学方法，用于发现具有治疗前景的新型抑制剂。
SAR QSAR Environ Res. 2025 Jan;36(1):1-28. doi: 10.1080/1062936X.2025.2452001. Epub 2025 Jan 23.
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Arginyltransferase ATE1 catalyzes midchain arginylation of proteins at side chain carboxylates in vivo.精氨酰转移酶ATE1在体内催化蛋白质侧链羧酸盐处的中链精氨酰化反应。
Chem Biol. 2014 Mar 20;21(3):331-7. doi: 10.1016/j.chembiol.2013.12.017. Epub 2014 Feb 13.
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Arginyltransferase 1 (ATE1)-mediated proteasomal degradation of viral haemagglutinin protein: a unique host defence mechanism.精氨酰-tRNA 合成酶 1（ATE1）介导的病毒血凝素蛋白的蛋白酶体降解：一种独特的宿主防御机制。
J Gen Virol. 2024 Aug;105(8). doi: 10.1099/jgv.0.002020.
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Analyzing N-terminal Arginylation through the Use of Peptide Arrays and Degradation Assays.通过使用肽阵列和降解试验分析N端精氨酰化
J Biol Chem. 2016 Sep 30;291(40):20976-20992. doi: 10.1074/jbc.M116.747956. Epub 2016 Aug 10.
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tRNA-Derived Fragments Can Serve as Arginine Donors for Protein Arginylation.转运RNA衍生片段可作为蛋白质精氨酰化的精氨酸供体。
Cell Chem Biol. 2020 Jul 16;27(7):839-849.e4. doi: 10.1016/j.chembiol.2020.05.013. Epub 2020 Jun 16.
引用本文的文献
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ATE1 promotes breast cancer progression via arginylation-dependent regulation of MAPK-MYC signaling.ATE1通过对MAPK-MYC信号通路的精氨酰化依赖性调控促进乳腺癌进展。
Cell Commun Signal. 2025 Sep 2;23(1):390. doi: 10.1186/s12964-025-02376-9.
2
SOD2 is a regulator of proteasomal degradation promoting an adaptive cellular starvation response.超氧化物歧化酶2（SOD2）是蛋白酶体降解的调节因子，可促进适应性细胞饥饿反应。
Cell Rep. 2025 Apr 22;44(4):115434. doi: 10.1016/j.celrep.2025.115434. Epub 2025 Mar 24.
3
A comprehensive Drosophila resource to identify key functional interactions between SARS-CoV-2 factors and host proteins.一个全面的果蝇资源，用于鉴定 SARS-CoV-2 因子与宿主蛋白之间的关键功能相互作用。
Cell Rep. 2023 Aug 29;42(8):112842. doi: 10.1016/j.celrep.2023.112842. Epub 2023 Jul 20.
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The N-degron pathway mediates lipophagy: The chemical modulation of lipophagy in obesity and NAFLD.N 去泛素化途径介导脂噬作用：肥胖和非酒精性脂肪性肝病中脂噬作用的化学调节。
Metabolism. 2023 Sep;146:155644. doi: 10.1016/j.metabol.2023.155644. Epub 2023 Jun 28.
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Assay of Arginyltransferase Activity by a Fluorescent HPLC Method.采用荧光高效液相色谱法测定精氨酰转移酶活性
Methods Mol Biol. 2023;2620:129-137. doi: 10.1007/978-1-0716-2942-0_18.
6
High-Throughput Arginylation Assay in Microplate Format.微孔板形式的高通量精氨酰化分析
Methods Mol Biol. 2023;2620:119-122. doi: 10.1007/978-1-0716-2942-0_16.
7
Bacterial Expression and Purification of Recombinant Arginyltransferase (ATE1) and Arg-tRNA Synthetase (RRS) for Arginylation Assays.用于精氨酰化测定的重组精氨酰转移酶（ATE1）和精氨酰-tRNA合成酶（RRS）的细菌表达与纯化
Methods Mol Biol. 2023;2620:87-91. doi: 10.1007/978-1-0716-2942-0_11.
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Assaying Arginylation Activity in Cell Lysates Using a Fluorescent Reporter.使用荧光报告分子测定细胞裂解物中的精氨酰化活性。
Methods Mol Biol. 2023;2620:71-80. doi: 10.1007/978-1-0716-2942-0_9.
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Protein Arginylation Is Regulated during SARS-CoV-2 Infection.蛋白精氨酸化在 SARS-CoV-2 感染过程中受到调控。
Viruses. 2023 Jan 19;15(2):290. doi: 10.3390/v15020290.
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Iron-sulfur clusters are involved in post-translational arginylation.铁硫簇参与翻译后精氨酸化。
Nat Commun. 2023 Jan 28;14(1):458. doi: 10.1038/s41467-023-36158-z.
本文引用的文献
1
Arginyltransferase is an ATP-independent self-regulating enzyme that forms distinct functional complexes in vivo.精氨酰转移酶是一种不依赖三磷酸腺苷（ATP）的自我调节酶，它在体内形成不同的功能复合物。
Chem Biol. 2011 Jan 28;18(1):121-30. doi: 10.1016/j.chembiol.2010.10.016.
2
Hemin binds to human cytoplasmic arginyl-tRNA synthetase and inhibits its catalytic activity.血红素与人细胞质精氨酰-tRNA 合成酶结合并抑制其催化活性。
J Biol Chem. 2010 Dec 10;285(50):39437-46. doi: 10.1074/jbc.M110.159913. Epub 2010 Oct 5.
3
Arginylation-dependent neural crest cell migration is essential for mouse development.精氨酸化依赖的神经嵴细胞迁移对于小鼠发育是必需的。
PLoS Genet. 2010 Mar 12;6(3):e1000878. doi: 10.1371/journal.pgen.1000878.
4
Arginylation regulates intracellular actin polymer level by modulating actin properties and binding of capping and severing proteins.精氨酸化通过调节肌动蛋白的性质和结合盖帽和切割蛋白来调节细胞内肌动蛋白聚合物水平。
Mol Biol Cell. 2010 Apr 15;21(8):1350-61. doi: 10.1091/mbc.e09-09-0829. Epub 2010 Feb 24.
5
Ablation of arginylation in the mouse N-end rule pathway: loss of fat, higher metabolic rate, damaged spermatogenesis, and neurological perturbations.在小鼠 N 端规则途径中消除精氨酸化作用：脂肪减少、代谢率升高、精子发生受损和神经扰动。
PLoS One. 2009 Nov 13;4(11):e7757. doi: 10.1371/journal.pone.0007757.
6
RGS5, a hypoxia-inducible apoptotic stimulator in endothelial cells.RGS5，一种内皮细胞中的缺氧诱导凋亡刺激因子。
J Biol Chem. 2009 Aug 28;284(35):23436-43. doi: 10.1074/jbc.M109.032664. Epub 2009 Jun 29.
7
Fibroblasts potentiate blood vessel formation partially through secreted factor TIMP-1.成纤维细胞部分通过分泌因子基质金属蛋白酶组织抑制因子-1来增强血管形成。
Angiogenesis. 2008;11(3):223-34. doi: 10.1007/s10456-008-9102-8. Epub 2008 Feb 14.
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The N-end rule pathway is a sensor of heme.N端规则途径是一种血红素传感器。
Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):76-81. doi: 10.1073/pnas.0710568105. Epub 2007 Dec 27.
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Global analysis of posttranslational protein arginylation.翻译后蛋白质精氨酰化的全局分析。
PLoS Biol. 2007 Oct;5(10):e258. doi: 10.1371/journal.pbio.0050258.
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Endothelial cell migration during angiogenesis.血管生成过程中的内皮细胞迁移。
Circ Res. 2007 Mar 30;100(6):782-94. doi: 10.1161/01.RES.0000259593.07661.1e.
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