Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.
Trends Immunol. 2012 Apr;33(4):168-73. doi: 10.1016/j.it.2012.01.010. Epub 2012 Feb 17.
T cell growth and function must be tightly regulated to provide protection against foreign pathogens, while avoiding autoimmunity and immunodeficiency. It is now apparent that T cell metabolism is highly dynamic and has a tremendous impact on the ability of T cells to grow, activate and differentiate. Specific metabolic pathways provide energy and biosynthetic precursors that must support specific cell functions, as effector, regulatory, memory, and alloreactive T cells have distinct metabolic needs in immunity and inflammation. Here, we review the signaling pathways that control metabolism and how the metabolic phenotypes of T cell subtypes integrate with T cell function. Ultimately, these metabolic differences may provide new opportunities to modulate the immune response and treat inflammatory and autoimmune diseases.
T 细胞的生长和功能必须受到严格的调控，以提供对外来病原体的保护，同时避免自身免疫和免疫缺陷。现在很明显，T 细胞代谢具有高度动态性，并对 T 细胞的生长、激活和分化能力产生巨大影响。特定的代谢途径提供能量和生物合成前体，这些物质必须支持特定的细胞功能，因为效应器、调节性、记忆性和同种反应性 T 细胞在免疫和炎症中具有不同的代谢需求。在这里，我们回顾了控制代谢的信号通路，以及 T 细胞亚群的代谢表型如何与 T 细胞功能整合。最终，这些代谢差异可能为调节免疫反应和治疗炎症性和自身免疫性疾病提供新的机会。
