Department of Ophthalmology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea.
Yonsei Med J. 2012 May;53(3):634-41. doi: 10.3349/ymj.2012.53.3.634.
To evaluate reliability of Fourier-domain optical coherence tomography (OCT) (RTVue), time-domain OCT (Visante), and slit-lamp adapted ultrasonic pachymetry (SL-US) in the measurement of central corneal thickness (CCT).
Thirty healthy volunteers visited our clinic 3 times and fifty eyes were measured by one physician. RTVue and Visante were randomly performed, and then SL-US, in which the ultrasound probe was inserted into the Goldmann tonometry mount, was done. During the second visit, each measurement was repeated 3 times. Measurements on the second visit were averaged, and agreement among the instruments was investigated with Bland-Altman plots.
RTVue showed smaller repeatability coefficient than Visante and SL-US (4.7, 8.3, and 7.7 μm, respectively). Intersession reproducibility of RTVue and Visante was worse than their repeatability. CCT of RTVue was estimated to be maximally different by 11.8 μm from CCT of Visante and 8.8 μm from CCT of SL-US. The repeatability coefficient of SL-US was 7.7 μm and its reproducibility was similar to the repeatability.
CCT measured by RTVue showed good reliability and generally agreed with Visante and SL-US. SL-US was as reliable as triple touching conventional US even with a single touch on the cornea.
评估傅里叶域光学相干断层扫描（OCT）（RTVue）、时域 OCT（Visante）和裂隙灯适配的超声角膜测厚仪（SL-US）在测量中央角膜厚度（CCT）方面的可靠性。
30 名健康志愿者 3 次就诊于我们的诊所，共 50 只眼由同一位医生进行测量。随机进行 RTVue 和 Visante 检查，然后将超声探头插入 Goldmann 眼压计的 SL-US 进行检查。第二次就诊时重复测量 3 次。第二次就诊时的测量结果取平均值，并通过 Bland-Altman 图来研究仪器之间的一致性。
RTVue 的重复性系数小于 Visante 和 SL-US（分别为 4.7、8.3 和 7.7μm）。RTVue 和 Visante 的两次就诊间的可重复性不如其重复性好。RTVue 测量的 CCT 与 Visante 测量的 CCT 相差最大可达 11.8μm，与 SL-US 测量的 CCT 相差最大可达 8.8μm。SL-US 的重复性系数为 7.7μm，其可重复性与重复性相似。
RTVue 测量的 CCT 具有良好的可靠性，通常与 Visante 和 SL-US 一致。SL-US 与传统的三次触诊超声一样可靠，即使单次触诊角膜也具有可靠性。
