Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310010, China.
Eye hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 32500, China.
BMC Med Imaging. 2023 Nov 21;23(1):194. doi: 10.1186/s12880-023-01147-7.
To evaluate the repeatability and agreement of Fourier-domain optical coherence tomography (AOCT-1000 M and RTVue XR) and partial coherence interferometry biometer (IOL Master 500) in measuring corneal thickness mapping and axial length respectively.
Corneal thickness was measured by AOCT-1000 M and RTVue XR. Axial lengths were measured by AOCT-1000 M and IOL Master 500. The repeatability and agreement of corneal thickness and axial length were calculated in two groups of devices. The intraclass correlation coefficient (ICC) was used to verify the repeatability of the device. The 95% confidence interval of the difference compared to the set cut-off value was used to verify the agreement between the two devices.
A total of 60 subjects with 58 eyes were included. The central corneal thickness measured by AOCT-1000 M and RTVue XR were 504.46 ± 42.53 μm and 504.43 ± 42.89 μm respectively. The average difference between groups was 0.03 ± 4.58 μm, and the 95% confidence interval was (-1.17, 1.24), which was far less than the set threshold value of 15 μm (P < 0.001). Both RTVue XR and AOCT-1000 M had very good ICC values of central corneal thickness (0.998 and 0.994, respectively). The average axial lengths measured by AOCT-1000 M and IOL Master 500 were 24.28 ± 1.25 mm and 24.29 ± 1.26 mm respectively and the 95% confidence interval was (-0.02, 0.01), which was less than the set threshold value of 0.15 mm (P < 0.001). The ICC for both devices were 1.000.
Good repeatability and agreement were seen in measurements of central corneal thickness and axial length by AOCT-1000 M.
评估傅里叶域光学相干断层扫描（AOCT-1000 M 和 RTVue XR）和部分相干干涉仪生物测量仪（IOL Master 500）在分别测量角膜厚度图谱和眼轴长度时的重复性和一致性。
使用 AOCT-1000 M 和 RTVue XR 测量角膜厚度。使用 AOCT-1000 M 和 IOL Master 500 测量眼轴长度。分别计算两组设备的角膜厚度和眼轴长度的重复性和一致性。使用组内相关系数（ICC）验证设备的重复性。使用与设定截止值的差异的 95%置信区间验证两种设备之间的一致性。
共纳入 60 例 58 只眼。AOCT-1000 M 和 RTVue XR 测量的中央角膜厚度分别为 504.46±42.53μm和 504.43±42.89μm。两组之间的平均差值为 0.03±4.58μm，95%置信区间为（-1.17，1.24），远小于设定的 15μm 阈值（P<0.001）。RTVue XR 和 AOCT-1000 M 的中央角膜厚度 ICC 值均非常高（分别为 0.998 和 0.994）。AOCT-1000 M 和 IOL Master 500 测量的平均眼轴长度分别为 24.28±1.25mm 和 24.29±1.26mm，95%置信区间为（-0.02，0.01），小于设定的 0.15mm 阈值（P<0.001）。两种设备的 ICC 值均为 1.000。
AOCT-1000 M 在测量中央角膜厚度和眼轴长度方面具有良好的重复性和一致性。
