Hampton F J, MacFadyen U M, Simpson H
Department of Child Health, Leicester Royal Infirmary.
Arch Dis Child. 1990 Nov;65(11):1249-54. doi: 10.1136/adc.65.11.1249.
Thirteen infants who had undergone 24 hour oesophageal pH monitoring to diagnose gastro-oesophageal reflux had a second study carried out to see if the results were reproducible. The studies were done without restricting the babies' activities. Appreciable differences were found, the percentage of the total time during which the pH was less than 4 varying by up to 3.7-fold between the two tests. The differences were largely the result of biological rather than technical variability. From these results estimates were made of the reliability of a single diagnostic study and the size of changes that would be necessary to show the effect of treatment. These findings have a considerable impact on the diagnosis of abnormal gastro-oesophageal reflux and its response to treatment whether using 24 hour pH monitoring or any other method of measurement.
13名接受了24小时食管pH监测以诊断胃食管反流的婴儿进行了第二项研究，以观察结果是否具有可重复性。这些研究在不限制婴儿活动的情况下进行。发现了明显差异，两次测试之间pH值低于4的总时间百分比变化高达3.7倍。这些差异主要是生物学而非技术变异性的结果。根据这些结果，对单一诊断研究的可靠性以及显示治疗效果所需的变化幅度进行了估计。这些发现对胃食管反流异常的诊断及其对治疗的反应有相当大的影响，无论使用24小时pH监测还是任何其他测量方法。
