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Multicentre prospective observational study on professional wound care using honey (Medihoney™).多中心前瞻性观察研究:医用蜂蜜(美皮康)在专业伤口护理中的应用。
Int Wound J. 2013 Jun;10(3):252-9. doi: 10.1111/j.1742-481X.2012.00970.x. Epub 2012 Apr 11.
2
Manuka honey vs. hydrogel--a prospective, open label, multicentre, randomised controlled trial to compare desloughing efficacy and healing outcomes in venous ulcers.麦卢卡蜂蜜与水凝胶——一项比较静脉性溃疡清创效果和愈合结果的前瞻性、开放标签、多中心随机对照试验。
J Clin Nurs. 2009 Feb;18(3):466-74. doi: 10.1111/j.1365-2702.2008.02558.x. Epub 2008 Aug 23.
3
Bacteriological changes in sloughy venous leg ulcers treated with manuka honey or hydrogel: an RCT.用麦卢卡蜂蜜或水凝胶治疗的腿部静脉溃疡腐肉的细菌学变化:一项随机对照试验。
J Wound Care. 2008 Jun;17(6):241-4, 246-7. doi: 10.12968/jowc.2008.17.6.29583.
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Effects of honey and sugar dressings on wound healing.蜂蜜和糖敷料对伤口愈合的影响。
J Wound Care. 2007 Jul;16(7):317-9. doi: 10.12968/jowc.2007.16.7.27053.
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The reality of routine practice: a pooled data analysis on chronic wounds treated with TLC-NOSF wound dressings.常规实践的现实情况:对使用TLC-NOSF伤口敷料治疗的慢性伤口进行的汇总数据分析。
J Wound Care. 2017 Feb;26(Sup2):S4-S15. doi: 10.12968/jowc.2017.26.Sup2.S4.
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Honey as a topical treatment for wounds.蜂蜜作为伤口的局部治疗方法。
Cochrane Database Syst Rev. 2008 Oct 8(4):CD005083. doi: 10.1002/14651858.CD005083.pub2.
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Applying honey dressings to non-healing wounds in elderly persons receiving home care.为接受居家护理的老年人应用蜂蜜敷料处理不愈合的伤口。
J Tissue Viability. 2019 Aug;28(3):139-143. doi: 10.1016/j.jtv.2019.04.002. Epub 2019 Apr 13.
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The impact of Manuka honey dressings on the surface pH of chronic wounds.麦卢卡蜂蜜敷料对慢性伤口表面pH值的影响。
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Opportunities for better value wound care: a multiservice, cross-sectional survey of complex wounds and their care in a UK community population.更好的价值伤口护理机会:英国社区人群中复杂伤口及其护理的多服务、横断面调查。
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Honey as a topical treatment for wounds.蜂蜜作为伤口的局部治疗方法。
Cochrane Database Syst Rev. 2013 Feb 28(2):CD005083. doi: 10.1002/14651858.CD005083.pub3.

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Honey as a Natural Antimicrobial.蜂蜜作为一种天然抗菌剂。
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The Use of Medical Grade Honey on Infected Chronic Diabetic Foot Ulcers-A Prospective Case-Control Study.医用级蜂蜜在感染性慢性糖尿病足溃疡中的应用——一项前瞻性病例对照研究。
Antibiotics (Basel). 2023 Aug 24;12(9):1364. doi: 10.3390/antibiotics12091364.
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Use of Medical-Grade Honey to Treat Clinically Infected Heel Pressure Ulcers in High-Risk Patients: A Prospective Case Series.使用医用级蜂蜜治疗高危患者临床感染的足跟压疮:一项前瞻性病例系列研究。
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Non-Healing Perianal Fistulas: A Clinical Model of Tissue Senescence Impairing Both Tissue Fibrosis and Regenerative Potential.难愈性肛周瘘管:一种损害组织纤维化和再生潜能的组织衰老临床模型。
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Infrared Thermography for Early Identification and Treatment of Shoulder Sores to Improve Sow and Piglet Welfare.用于早期识别和治疗肩部溃疡以改善母猪和仔猪福利的红外热成像技术。
Animals (Basel). 2022 Nov 14;12(22):3136. doi: 10.3390/ani12223136.
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Honey in wound healing: An updated review.蜂蜜在伤口愈合中的应用:最新综述。
Open Life Sci. 2021 Oct 6;16(1):1091-1100. doi: 10.1515/biol-2021-0084. eCollection 2021.
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Medical-Grade Honey as an Alternative Treatment for Antibiotics in Non-Healing Wounds-A Prospective Case Series.医用级蜂蜜作为非愈合伤口抗生素替代治疗的前瞻性病例系列研究
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A Comparison of the Effects of Topical Prolavacid Solution (a Polyhexamethylene Biguanide-Based Wound Cleanser) and Medihoney Ointment in a Rat Model of Cutaneous Wound.局部用普罗拉维酸溶液(一种基于聚六亚甲基双胍的伤口清洁剂)与医用蜂蜜软膏在大鼠皮肤伤口模型中的效果比较
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Therapeutic Manuka Honey: No Longer So Alternative.治疗性麦卢卡蜂蜜:不再那么另类。
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Ulcerated tophaceous gout.溃疡性痛风石性痛风
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本文引用的文献

1
The effect of honey-coated bandages compared with silver-coated bandages on treatment of malignant wounds-a randomized study.蜂蜜涂层绷带与银涂层绷带治疗恶性伤口的效果比较:一项随机研究。
Wound Repair Regen. 2011 Nov;19(6):664-70. doi: 10.1111/j.1524-475X.2011.00735.x. Epub 2011 Oct 13.
2
Randomised controlled feasibility trial on the use of medical grade honey following microvascular free tissue transfer to reduce the incidence of wound infection.关于在微血管游离组织移植后使用医用级蜂蜜以降低伤口感染发生率的随机对照可行性试验。
Br J Oral Maxillofac Surg. 2012 Jun;50(4):321-7. doi: 10.1016/j.bjoms.2011.07.014. Epub 2011 Aug 9.
3
Medical-grade honey enriched with antimicrobial peptides has enhanced activity against antibiotic-resistant pathogens.医用级蜂蜜富含具有抗菌活性的抗菌肽,能增强其对抗抗生素耐药病原体的活性。
Eur J Clin Microbiol Infect Dis. 2011 Feb;30(2):251-7. doi: 10.1007/s10096-010-1077-x. Epub 2010 Oct 7.
4
Absence of bacterial resistance to medical-grade manuka honey.医用级麦卢卡蜂蜜不存在细菌耐药性。
Eur J Clin Microbiol Infect Dis. 2010 Oct;29(10):1237-41. doi: 10.1007/s10096-010-0992-1. Epub 2010 Jun 13.
5
Understanding wound bed preparation and wound debridement.了解伤口床准备和伤口清创术。
Br J Community Nurs. 2010 Mar;15(3):S22, S24, S26, passim. doi: 10.12968/bjcn.2010.15.Sup12.S22.
6
Is manuka honey the best type of honey for wound care?麦卢卡蜂蜜是伤口护理的最佳蜂蜜类型吗?
J Hosp Infect. 2010 Mar;74(3):305-6. doi: 10.1016/j.jhin.2009.08.010. Epub 2009 Nov 10.
7
Effect of honey and its major royal jelly protein 1 on cytokine and MMP-9 mRNA transcripts in human keratinocytes.蜂蜜及其主要蜂王浆蛋白 1 对人角质形成细胞细胞因子和 MMP-9 mRNA 转录本的影响。
Exp Dermatol. 2010 Aug;19(8):e73-9. doi: 10.1111/j.1600-0625.2009.00994.x.
8
Topical antimicrobial agents for the treatment of chronic wounds.用于治疗慢性伤口的局部抗菌剂。
Br J Community Nurs. 2009 Sep;14(9):S6, S8, S10 passim. doi: 10.12968/bjcn.2009.14.Sup4.43909.
9
The unusual antibacterial activity of medical-grade Leptospermum honey: antibacterial spectrum, resistance and transcriptome analysis.医用级麦卢卡蜂蜜的独特抗菌活性:抗菌谱、耐药性及转录组分析。
Eur J Clin Microbiol Infect Dis. 2009 Oct;28(10):1199-208. doi: 10.1007/s10096-009-0763-z. Epub 2009 Jun 10.
10
The honeypot study protocol: a randomized controlled trial of exit-site application of medihoney antibacterial wound gel for the prevention of catheter-associated infections in peritoneal dialysis patients.蜜罐研究方案:一项关于在腹膜透析患者中应用Medihoney抗菌伤口凝胶进行出口部位护理以预防导管相关感染的随机对照试验。
Perit Dial Int. 2009 May-Jun;29(3):303-9.

多中心前瞻性观察研究:医用蜂蜜(美皮康)在专业伤口护理中的应用。

Multicentre prospective observational study on professional wound care using honey (Medihoney™).

机构信息

Department of Paraplegia and Technical Orthopaedics, Insurance Association Trauma Centre, 67071 Ludwigshafen, Germany.

出版信息

Int Wound J. 2013 Jun;10(3):252-9. doi: 10.1111/j.1742-481X.2012.00970.x. Epub 2012 Apr 11.

DOI:10.1111/j.1742-481X.2012.00970.x
PMID:22494449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7950896/
Abstract

In recent years, the treatment of wounds with honey has received an increasing amount of attention from healthcare professionals in Germany and Austria. We conducted a prospective observational multicentre study using Medihoney™ dressings in 10 hospitals - nine in Germany and one in Austria. Wound-associated parameters were monitored systematically at least three times in all patients. Data derived from the treatment of 121 wounds of various aetiologies over a period of 2 years were analysed. Almost half of the patients were younger than 18 years old, and 32% of the study population was oncology patients. Overall, wound size decreased significantly during the study period and many wounds healed after relatively short time periods. Similarly, perceived pain levels decreased significantly, and the wounds showed noticeably less slough/necrosis. In general, our findings show honey to be an effective and feasible treatment option for professional wound care. In addition, our study showed a relationship between pain and slough/necrosis at the time of recruitment and during wound healing. Future comparative trials are still needed to evaluate the extent to which the positive observations made in this and other studies can definitely be attributed to the effects of honey in wound care.

摘要

近年来,德国和奥地利的医疗保健专业人员越来越关注使用蜂蜜治疗伤口。我们在 10 家医院(德国 9 家,奥地利 1 家)进行了一项前瞻性观察性多中心研究,使用 Medihoney™敷料对所有患者至少进行了 3 次系统监测。分析了为期 2 年治疗的 121 种不同病因的伤口数据。将近一半的患者年龄小于 18 岁,32%的研究人群为肿瘤患者。总的来说,研究期间伤口大小明显缩小,许多伤口在较短的时间内愈合。同样,疼痛程度明显降低,伤口的腐肉/坏死明显减少。总体而言,我们的研究结果表明蜂蜜是一种有效且可行的专业伤口护理治疗选择。此外,我们的研究还表明,招募时和伤口愈合过程中的疼痛与腐肉/坏死之间存在关联。仍需要进行未来的对照试验,以评估在本研究和其他研究中观察到的积极结果在多大程度上可以归因于蜂蜜在伤口护理中的作用。