Nafeeza M I, Isa M R, Kudva M V, Ishak M S, Mazlam M Z, Haron A, Najib R, Shahimi M M
Departments of Pharmacology.
Malays J Med Sci. 2000 Jan;7(1):22-6.
The objective of the study was to determine the prevalence of H. pylori in functional dyspepsia among the three main races in Malaysia. Gastric antral biopsies from 233 (98 males, 135 females; age range: 17-75 years, mean age 39.5 years) patients attending the Universiti Kebangsaan Malaysia (UKM) gastroenterology clinic were assessed for the presence of H. pylori by culture and histology. About a third of the cases (79 of 233 (34%); 34 males, 45 females; mean age 42.6 yrs) were positive for H. pylori. The presence of H. pylori was always associated with antral gastritis. Malay patients were least likely to be positive for H. pylori (10 of 88 (11.4%); 5 males, 5 females; mean age 35.7 yrs) compared to the Chinese (43 of 95 (45%); 19 males; 24 females; mean age 40.2 yrs) and Indian patients (23 of 41 (56%); 10 males, 13 females; mean age 48.1 yrs). We found that H. pylori were most common among Chinese followed by Indians. However, the relative risk for the Indians was 8.58 and 6.29 for the Chinese compared to Malays. We conclude that the prevalence of H. pylori in patients with functional dyspepsia differs considerably with respect to ethnic groups.
该研究的目的是确定马来西亚三个主要种族中功能性消化不良患者幽门螺杆菌的感染率。对233名（98名男性，135名女性；年龄范围：17 - 75岁，平均年龄39.5岁）前往马来西亚国民大学（UKM）胃肠病诊所就诊的患者进行胃窦活检，通过培养和组织学方法评估幽门螺杆菌的存在情况。约三分之一的病例（233例中的79例（34%）；34名男性，45名女性；平均年龄42.6岁）幽门螺杆菌检测呈阳性。幽门螺杆菌的存在总是与胃窦炎相关。与华裔（95例中的43例（45%）；19名男性，24名女性；平均年龄40.2岁）和印裔患者（41例中的23例（56%）；10名男性，13名女性；平均年龄48.1岁）相比，马来患者幽门螺杆菌检测呈阳性的可能性最小（88例中的10例（11.4%）；5名男性，5名女性；平均年龄35.7岁）。我们发现幽门螺杆菌在华裔中最为常见，其次是印裔。然而，与马来人相比，印裔的相对风险为8.58，华裔为6.29。我们得出结论，功能性消化不良患者中幽门螺杆菌的感染率在不同种族之间存在显著差异。
