B 系的衰老和幼态持续。
Aging and neoteny in the B lineage.
机构信息
Department of Immunology, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel.
出版信息
Blood. 2012 Nov 15;120(20):4143-9. doi: 10.1182/blood-2012-07-444711. Epub 2012 Aug 30.
Abstract
Aging and the physiologic decline of tissues and cells were once thought to be irreversible. However, recent studies suggest that various tissues, especially parts of the hematopoietic system, can be rejuvenated. Here we review potential mechanisms for this process and how they may be used to reverse age-related disorders and aging in general. We propose the novel hypothesis that altering the homeostatic process during cellular depletion can reverse aging in the hematopoietic system.
摘要
衰老和组织及细胞的生理衰退曾被认为是不可逆转的。然而，最近的研究表明，各种组织，特别是造血系统的某些部分，可以被恢复年轻。在此，我们综述了这一过程的潜在机制，以及如何利用这些机制来逆转与年龄相关的疾病和衰老。我们提出了一个新颖的假说，即改变细胞耗竭过程中的动态平衡可以逆转造血系统的衰老。
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