21 天的丹尼尔饮食法加上或不加上磷虾油补充剂可改善男性和女性的人体测量参数和心脏代谢特征。
A 21-day Daniel fast with or without krill oil supplementation improves anthropometric parameters and the cardiometabolic profile in men and women.
机构信息
Cardiorespiratory/Metabolic Laboratory, 161 Roane Field House, University of Memphis, Memphis, TN, 38152, USA.
出版信息
Nutr Metab (Lond). 2012 Sep 13;9(1):82. doi: 10.1186/1743-7075-9-82.
BACKGROUND
The Daniel Fast is a vegan diet that prohibits the consumption of animal products, refined foods, white flour, preservatives, additives, sweeteners, flavorings, caffeine, and alcohol. Following this dietary plan for 21 days has been demonstrated to improve blood pressure, LDL-C, and certain markers of oxidative stress, but it has also been shown to lower HDL-C. Krill oil supplementation has been shown to increase HDL-C.
METHODS
We investigated the effects of following a Daniel Fast dietary plan with either krill oil supplementation (2 g/day) or placebo supplementation (coconut oil; 2 g/day) for 21 days. The subjects in this study (12 men and 27 women) were heterogeneous with respect to body mass index (BMI) (normal weight, overweight, and obese), blood lipids (normolipidemic and hyperlipidemic), blood glucose (normal fasting glucose, impaired fasting glucose, and type 2 diabetic), and blood pressure (normotensive and hypertensive).
RESULTS
Krill oil supplementation had no effect on any outcome measure (all p > 0.05), and so the data from the krill oil group and the placebo group were collapsed and analyzed to examine the effects of following a 21-day Daniel Fast. Significant reductions were observed in LDL-C (100.6 ± 4.3 mg/dL vs. 80.0 ± 3.7 mg/dL), the LDL:HDL ratio (2.0 ± 0.1 vs. 1.7 ± 0.1), fasting blood glucose (101.4 ± 7.5 mg/dL vs. 91.7 ± 3.4 mg/dL), fasting blood insulin (7.92 ± 0.80 μU/mL vs. 5.76 ± 0.59 μU/mL), homeostasis model assessment of insulin resistance (HOMA-IR) (2.06 ± 0.30 vs. 1.40 ± 0.21), systolic BP (110.7 ± 2.2 mm Hg vs. 105.5 ± 1.7 mm Hg), and body weight (74.1 ± 2.4 kg vs. 71.5 ± 2.3 kg) (all p < 0.05).
CONCLUSION
Following a Daniel Fast dietary plan improves a variety of cardiometabolic parameters in a wide range of individuals in as little as 21 days, and these improvements are unaffected by krill oil supplementation.
TRIAL REGISTRATION
Clinicaltrial.govNCT01378767.
背景
丹尼尔饮食法是一种纯素饮食，禁止食用动物产品、精制食品、白面粉、防腐剂、添加剂、甜味剂、调味料、咖啡因和酒精。遵循这种饮食计划 21 天已被证明可以改善血压、LDL-C 和某些氧化应激标志物，但也已被证明会降低 HDL-C。补充磷虾油已被证明可以增加 HDL-C。
方法
我们研究了在 21 天内遵循丹尼尔饮食法并补充磷虾油（每天 2 克）或安慰剂（椰子油；每天 2 克）对各种人群的影响。本研究的受试者（12 名男性和 27 名女性）在体重指数（BMI）（正常体重、超重和肥胖）、血脂（正常血脂和高脂血症）、血糖（空腹血糖正常、空腹血糖受损和 2 型糖尿病）和血压（正常血压和高血压）方面存在异质性。
结果
磷虾油补充剂对任何结果测量都没有影响（均 p>0.05），因此将磷虾油组和安慰剂组的数据合并分析，以检查遵循 21 天丹尼尔饮食法的效果。LDL-C（100.6±4.3 mg/dL 与 80.0±3.7 mg/dL）、LDL:HDL 比值（2.0±0.1 与 1.7±0.1）、空腹血糖（101.4±7.5 mg/dL 与 91.7±3.4 mg/dL）、空腹胰岛素（7.92±0.80 μU/mL 与 5.76±0.59 μU/mL）、胰岛素抵抗稳态模型评估（HOMA-IR）（2.06±0.30 与 1.40±0.21）、收缩压（110.7±2.2 mmHg 与 105.5±1.7 mmHg）和体重（74.1±2.4 kg 与 71.5±2.3 kg）均显著降低（均 p<0.05）。
结论
在短短 21 天内，遵循丹尼尔饮食法可改善各种心血管代谢参数，而且这种改善不受磷虾油补充剂的影响。
试验注册
Clinicaltrial.govNCT01378767。
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