心脏疾病中的再生-细胞外基质是关键吗？
Regeneration in heart disease-Is ECM the key?
机构信息
Cardiac Muscle Research Laboratory, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA 02115, USA.
出版信息
Life Sci. 2012 Oct 29;91(17-18):823-7. doi: 10.1016/j.lfs.2012.08.034. Epub 2012 Sep 12.
Abstract
The heart possesses a regeneration potential derived from endogenous and exogenous stem and progenitor cell populations, though baseline regeneration appears to be sub-therapeutic. This limitation was initially attributed to a lack of cells with cardiomyogenic potential following an insult to the myocardium. Rather, recent studies demonstrate increased numbers of cardiomyocyte progenitor cells in diseased hearts. Given that the limiting factor does not appear to be cell quantity but rather repletion of functional cardiomyocytes, it is crucial to understand potential mechanisms inhibiting progenitor cell differentiation. One of the extensively studied areas in heart disease is extracellular matrix (ECM) remodeling, with both the composition and mechanical properties of the ECM undergoing changes in diseased hearts. This review explores the influence of ECM properties on cardiomyogenesis and adult cardiac progenitor cells.
摘要
心脏具有源自内源性和外源性干细胞和祖细胞群体的再生潜力，尽管基线再生似乎治疗效果不佳。这种局限性最初归因于心肌损伤后具有心肌生成潜能的细胞数量不足。然而，最近的研究表明，患病心脏中存在更多的心肌细胞祖细胞。鉴于限制因素似乎不是细胞数量，而是功能性心肌细胞的补充，因此了解潜在的抑制祖细胞分化的机制至关重要。心脏病研究中广泛研究的一个领域是细胞外基质 (ECM) 重塑，患病心脏的 ECM 组成和机械特性都发生了变化。本综述探讨了 ECM 特性对心肌发生和成年心脏祖细胞的影响。
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