Dept of Restorative Dentistry, Periodontology and Endodontology, University of Medicine, Ernst-Moritz-Arndt University Greifswald, Greifswald.
Eur Respir J. 2013 Dec;42(6):1524-35. doi: 10.1183/09031936.00109112. Epub 2012 Dec 6.
This study aimed to assess the potential association of periodontal diseases with lung volumes and airflow limitation in a general adult population. Based on a representative population sample of the Study of Health in Pomerania (SHIP), 1463 subjects aged 25-86 years were included. Periodontal status was assessed by clinical attachment loss (CAL), probing depth and number of missing teeth. Lung function was measured using spirometry, body plethysmography and diffusing capacity of the lung for carbon monoxide. Linear regression models using fractional polynomials were used to assess associations between periodontal disease and lung function. Fibrinogen and high-sensitivity C-reactive protein (hs-CRP) were evaluated as potential intermediate factors. After full adjustment for potential confounders mean CAL was significantly associated with variables of mobile dynamic and static lung volumes, airflow limitation and hyperinflation (p<0.05). Including fibrinogen and hs-CRP did not change coefficients of mean CAL; associations remained statistically significant. Mean CAL was not associated with total lung capacity and diffusing capacity of the lung for carbon monoxide. Associations were confirmed for mean probing depth, extent measures of CAL/probing depth and number of missing teeth. Periodontal disease was significantly associated with reduced lung volumes and airflow limitation in this general adult population sample. Systemic inflammation did not provide a mechanism linking both diseases.
本研究旨在评估一般成年人群中牙周病与肺容积和气流受限的潜在关联。基于对波美拉尼亚健康研究（SHIP）的代表性人群样本，纳入了 1463 名 25-86 岁的受试者。牙周状况通过临床附着丧失（CAL）、探诊深度和缺失牙齿数来评估。使用肺活量计、体描法和一氧化碳弥散量测量肺功能。使用分数多项式的线性回归模型来评估牙周病与肺功能之间的关联。纤维蛋白原和高敏 C 反应蛋白（hs-CRP）被评估为潜在的中间因素。在充分调整潜在混杂因素后，平均 CAL 与移动动态和静态肺容积、气流受限和过度充气的变量显著相关（p<0.05）。包括纤维蛋白原和 hs-CRP 并没有改变平均 CAL 的系数；关联仍然具有统计学意义。平均 CAL 与总肺活量和一氧化碳弥散量无关。平均探诊深度、CAL/探诊深度的程度测量和缺失牙齿数的关联得到了证实。在这个一般成年人群样本中，牙周病与肺容积减少和气流受限显著相关。系统性炎症并没有提供连接这两种疾病的机制。
