Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, Avenida dos Bandeirantes 3900, Ribeirão Preto, SP, 14049-900, Brazil.
Eur J Clin Microbiol Infect Dis. 2013 Jun;32(6):723-8. doi: 10.1007/s10096-013-1813-0. Epub 2013 Jan 22.
In recent years we have observed great advances in our ability to combat infectious diseases. Through the development of novel genetic methodologies, including a better understanding of pathogen biology, pathogenic mechanisms, advances in vaccine development, designing new therapeutic drugs, and optimization of diagnostic tools, significant infectious diseases are now better controlled. Here, we briefly describe recent reports in the literature concentrating on infectious disease control. The focus of this review is to describe the molecular methods widely used in the diagnosis, prevention, and control of infectious diseases with regard to the innovation of molecular techniques. Since the list of pathogenic microorganisms is extensive, we emphasize some of the major human infectious diseases (AIDS, tuberculosis, malaria, rotavirus, herpes virus, viral hepatitis, and dengue fever). As a consequence of these developments, infectious diseases will be more accurately and effectively treated; safe and effective vaccines are being developed and rapid detection of infectious agents now permits countermeasures to avoid potential outbreaks and epidemics. But, despite considerable progress, infectious diseases remain a strong challenge to human survival.
近年来，我们在对抗传染病的能力方面取得了巨大的进步。通过开发新的遗传方法，包括更好地了解病原体生物学、发病机制、疫苗开发的进展、设计新的治疗药物以及优化诊断工具，现在可以更好地控制许多重大传染病。在这里，我们简要描述了文献中的最新报告，重点关注传染病的控制。本综述的重点是描述在诊断、预防和控制传染病方面广泛应用的分子方法，以及分子技术的创新。由于致病微生物的种类繁多，我们强调了一些主要的人类传染病（艾滋病、结核病、疟疾、轮状病毒、疱疹病毒、病毒性肝炎和登革热）。由于这些发展，传染病的治疗将更加准确和有效；正在开发安全有效的疫苗，并且对传染病原体的快速检测现在可以采取措施避免潜在的爆发和流行。但是，尽管取得了相当大的进展，传染病仍然是对人类生存的巨大挑战。
