Department of Nutritional Sciences, University of Cincinnati Medical Center, Cincinnati, OH 45267-0394, United States.
Diabetes Res Clin Pract. 2013 May;100(2):265-71. doi: 10.1016/j.diabres.2013.03.013. Epub 2013 Mar 27.
High consumption of dietary fructose has been shown to contribute to dyslipidemia and elevated blood pressure in adults, but there are few data in youth, particularly those at greater risk of cardiovascular disease (CVD). The aim of this study was to examine the association between fructose intake and CVD risk factors in a diverse population of youth with type 1 diabetes (T1D).
This was a cross-sectional analysis of data from the SEARCH for Diabetes in Youth study, including 2085 youth ages 10-22 years with T1D, of which 22% were racial/ethnic minority and 50% were female. A semi-quantitative food frequency questionnaire was used to assess intake.
Median daily fructose consumption was 7.9% of total calories. Fructose intake was positively associated with triglycerides (p<.01), but not with total cholesterol, LDL-cholesterol, HDL-cholesterol, or blood pressure after adjustment for physical activity and socio-demographic, clinical, and dietary covariates. An increase in fructose intake of 22 g (equivalent to a 12 oz can of soda) was associated with 23% higher odds of borderline/high versus low triglycerides (p<.005).
These data suggest that children with T1D should moderate their intake of fructose, particularly those with borderline or high triglycerides.
大量摄入膳食果糖已被证明会导致成年人血脂异常和血压升高，但在年轻人中，特别是在那些患心血管疾病（CVD）风险较高的人群中，相关数据较少。本研究旨在探讨在患有 1 型糖尿病（T1D）的不同人群中，果糖摄入量与 CVD 风险因素之间的关系。
这是对 SEARCH for Diabetes in Youth 研究数据的横断面分析，共纳入 2085 名年龄在 10-22 岁的 T1D 青少年，其中 22%为少数民族，50%为女性。采用半定量食物频率问卷评估摄入量。
中位数每日果糖摄入量占总卡路里的 7.9%。果糖摄入量与甘油三酯呈正相关（p<.01），但与总胆固醇、LDL-胆固醇、HDL-胆固醇或血压无关，调整了体力活动和社会人口统计学、临床和饮食协变量后。果糖摄入量增加 22 克（相当于一罐 12 盎司的苏打水）与边缘/高甘油三酯的几率增加 23%相关（p<.005）。
这些数据表明，T1D 儿童应适度摄入果糖，特别是那些边缘或高甘油三酯的儿童。
