埃塞俄比亚传统人类伤口治疗中所选药用植物的抗菌活性
Antibacterial activities of selected medicinal plants in traditional treatment of human wounds in Ethiopia.
作者信息
Taye Biruhalem, Giday Mirutse, Animut Abebe, Seid Jemal
机构信息
Aklilu Lemma Institute of Pathobiology, P.O. Box 1176, Addis Ababa University, Addis Ababa, Ethiopia.
出版信息
Asian Pac J Trop Biomed. 2011 Oct;1(5):370-5. doi: 10.1016/S2221-1691(11)60082-8.
Abstract
OBJECTIVE
To evaluate the activity of selected Ethiopian medicinal plants traditionally used for wound treatment against wound-causing bacteria.
METHODS
Samples of medicinal plants (Achyranthes aspera, Brucea antidysenterica, Datura stramonium, Croton macrostachyus, Acokanthera schimperi, Phytolacca dodecandra, Millettia ferruginea, and Solanum incanum) were extracted using absolute methanol and water and tested for their antimicrobial activities against clinical isolates and standard strains of wound-causing bacteria using agar well diffusion and micro titer plate methods.
RESULTS
Most of the plant extracts had antibacterial activities, among which Acokanthera schimperi and Brucea antidysenterica inhibited growth of 100% and 35% of the test organisms, respectively. Methanolic extracts had higher activities compared with their corresponding aqueous extracts. The most susceptible organism to the extracts was Streptococcus pyogens while the most resistant were Escherichia coli and Proteus vulgaris.
CONCLUSIONS
This finding justifies the use of the plants in wound healing and their potential activity against wound-causing bacteria. Their toxicity level and antimicrobial activity with different extraction solvents should further be studied to use them as sources and templates for the synthesis of drugs to control wound and other disease-causing bacteria.
摘要
目的
评估埃塞俄比亚传统上用于伤口治疗的药用植物对致伤细菌的活性。
方法
采用无水甲醇和水对药用植物（牛膝、鸦胆子、曼陀罗、大戟、箭毒木、商陆、铁刀木和白英）样本进行提取，并使用琼脂孔扩散法和微量滴定板法检测其对临床分离株和致伤细菌标准菌株的抗菌活性。
结果
大多数植物提取物具有抗菌活性，其中箭毒木和鸦胆子分别抑制了100%和35%的受试微生物生长。甲醇提取物的活性高于相应的水提取物。提取物最敏感的微生物是化脓性链球菌，而最耐药的是大肠杆菌和普通变形杆菌。
结论
这一发现证明了这些植物在伤口愈合中的应用及其对致伤细菌的潜在活性。应进一步研究它们在不同提取溶剂中的毒性水平和抗菌活性，以便将其用作合成控制伤口及其他致病细菌药物的来源和模板。
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