男性 HPV 感染（HIM）研究中男性生殖器部位 HPV 的广泛分布。
Broad HPV distribution in the genital region of men from the HPV infection in men (HIM) study.
机构信息
Molecular Biology Laboratory, Center of Translational Oncology, Instituto do Câncer do Estado de São Paulo--ICESP, São Paulo 01246-000, Brazil.
出版信息
Virology. 2013 Sep 1;443(2):214-7. doi: 10.1016/j.virol.2013.04.024. Epub 2013 May 28.
Abstract
The HPV infection in men (HIM) study examines the natural history of genital HPV infection in men. Genotyping methods used in this study identify 37 α-HPV types; however, the viral type could not be identified in approximately 22% of male genital specimens that were HPV PCR positive. Our aim was to genotype HPV-unclassified specimens by sequencing PGMY09/11, GP5+/6+ or FAP59/64 PCR products. Using this approach we were able to detect 86 unique HPV types among 508 of 931 specimens analyzed. We report for the first time the presence of a broad range of α-, β- and γ-HPV at the male genitals.
摘要
男性人乳头瘤病毒（HPV）感染研究（HIM 研究）旨在探究男性生殖器 HPV 感染的自然史。本研究采用的基因分型方法可鉴定 37 种 α-HPV 型别；然而，在 HPV PCR 阳性的大约 22%男性生殖器标本中，无法鉴定 HPV 病毒型别。我们的目的是通过测序 PGMY09/11、GP5+/6+或 FAP59/64 PCR 产物对 HPV 未分类标本进行基因分型。通过该方法，我们在分析的 931 个标本中的 508 个标本中检测到了 86 种 HPV 独特型别。我们首次报道了在男性生殖器存在广泛的 α-、β-和 γ-HPV 型别。
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