Tzeng Stephany Y, Green Jordan J
Department of Biomedical Engineering, Baltimore, MD 21231, USA.
Ther Deliv. 2013 Jun;4(6):687-704. doi: 10.4155/tde.13.38.
Malignant brain cancer treatment is limited by a number of barriers, including the blood-brain barrier, transport within the brain interstitium, difficulties in delivering therapeutics specifically to tumor cells, the highly invasive quality of gliomas and drug resistance. As a result, the prognosis for patients with high-grade gliomas is poor and has improved little in recent years. Nanomedicine approaches have been developed in the laboratory, with some technologies being translated to the clinic, in order to address these needs. This review discusses the obstacles to effective treatment that are currently faced in the field, as well as various nanomedicine techniques that have been used or are being explored to overcome them, with a focus on liposomal and polymeric nanoparticles.
恶性脑癌的治疗受到多种障碍的限制，包括血脑屏障、脑间质内的转运、将治疗药物特异性递送至肿瘤细胞的困难、胶质瘤的高度侵袭性以及耐药性。因此，高级别胶质瘤患者的预后很差，近年来几乎没有改善。为了满足这些需求，实验室已开发出纳米医学方法，一些技术已转化至临床应用。本综述讨论了该领域目前在有效治疗方面面临的障碍，以及已被使用或正在探索用于克服这些障碍的各种纳米医学技术，重点是脂质体和聚合物纳米颗粒。
