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荷兰计划在家分娩与医院分娩的低危产妇严重不良母婴结局比较:全国队列研究。

Severe adverse maternal outcomes among low risk women with planned home versus hospital births in the Netherlands: nationwide cohort study.

机构信息

Department of Midwifery Science, AVAG and the EMGO Institute of Health and Care Research, VU University Medical Center, Amsterdam, Netherlands.

出版信息

BMJ. 2013 Jun 13;346:f3263. doi: 10.1136/bmj.f3263.

Abstract

OBJECTIVES

To test the hypothesis that low risk women at the onset of labour with planned home birth have a higher rate of severe acute maternal morbidity than women with planned hospital birth, and to compare the rate of postpartum haemorrhage and manual removal of placenta.

DESIGN

Cohort study using a linked dataset.

SETTING

Information on all cases of severe acute maternal morbidity in the Netherlands collected by the national study into ethnic determinants of maternal morbidity in the netherlands (LEMMoN study), 1 August 2004 to 1 August 2006, merged with data from the Netherlands perinatal register of all births occurring during the same period.

PARTICIPANTS

146 752 low risk women in primary care at the onset of labour.

MAIN OUTCOME MEASURES

Severe acute maternal morbidity (admission to an intensive care unit, eclampsia, blood transfusion of four or more packed cells, and other serious events), postpartum haemorrhage, and manual removal of placenta.

RESULTS

Overall, 92 333 (62.9%) women had a planned home birth and 54 419 (37.1%) a planned hospital birth. The rate of severe acute maternal morbidity among planned primary care births was 2.0 per 1000 births. For nulliparous women the rate for planned home versus planned hospital birth was 2.3 versus 3.1 per 1000 births (adjusted odds ratio 0.77, 95% confidence interval 0.56 to 1.06), relative risk reduction 25.7% (95% confidence interval -0.1% to 53.5%), the rate of postpartum haemorrhage was 43.1 versus 43.3 (0.92, 0.85 to 1.00 and 0.5%, -6.8% to 7.9%), and the rate of manual removal of placenta was 29.0 versus 29.8 (0.91, 0.83 to 1.00 and 2.8%, -6.1% to 11.8%). For parous women the rate of severe acute maternal morbidity for planned home versus planned hospital birth was 1.0 versus 2.3 per 1000 births (0.43, 0.29 to 0.63 and 58.3%, 33.2% to 87.5%), the rate of postpartum haemorrhage was 19.6 versus 37.6 (0.50, 0.46 to 0.55 and 47.9%, 41.2% to 54.7%), and the rate of manual removal of placenta was 8.5 versus 19.6 (0.41, 0.36 to 0.47 and 56.9%, 47.9% to 66.3%).

CONCLUSIONS

Low risk women in primary care at the onset of labour with planned home birth had lower rates of severe acute maternal morbidity, postpartum haemorrhage, and manual removal of placenta than those with planned hospital birth. For parous women these differences were statistically significant. Absolute risks were small in both groups. There was no evidence that planned home birth among low risk women leads to an increased risk of severe adverse maternal outcomes in a maternity care system with well trained midwives and a good referral and transportation system.

摘要

目的

检验以下假设,即在分娩开始时计划在家分娩的低危女性出现严重急性产妇发病率高于计划在医院分娩的女性,并且比较产后出血和人工胎盘剥离的发生率。

设计

使用关联数据集的队列研究。

地点

荷兰全国少数民族产妇发病率决定因素研究(LEMMoN 研究)收集的所有严重急性产妇发病率病例信息,2004 年 8 月 1 日至 2006 年 8 月 1 日,与同期所有分娩的荷兰围产期登记处的数据合并。

参与者

146752 名在初级保健分娩开始时的低危女性。

主要观察指标

严重急性产妇发病率(入住重症监护病房、子痫、输注四个或更多单位的浓缩红细胞和其他严重事件)、产后出血和人工胎盘剥离。

结果

总体而言,92333 名(62.9%)女性计划在家分娩,54419 名(37.1%)计划在医院分娩。初级保健分娩的严重急性产妇发病率为每 1000 例 2.0 例。对于初产妇,计划在家分娩与计划在医院分娩的严重急性产妇发病率分别为 2.3 比 3.1 每 1000 例(调整后的优势比 0.77,95%置信区间 0.56 至 1.06),相对风险降低 25.7%(95%置信区间-0.1%至 53.5%),产后出血率为 43.1 比 43.3(0.92,0.85 至 1.00 和 0.5%,-6.8%至 7.9%),人工胎盘剥离率为 29.0 比 29.8(0.91,0.83 至 1.00 和 2.8%,-6.1%至 11.8%)。对于经产妇,计划在家分娩与计划在医院分娩的严重急性产妇发病率分别为 1.0 比 2.3 每 1000 例(0.43,0.29 至 0.63 和 58.3%,33.2%至 87.5%),产后出血率为 19.6 比 37.6(0.50,0.46 至 0.55 和 47.9%,41.2%至 54.7%),人工胎盘剥离率为 8.5 比 19.6(0.41,0.36 至 0.47 和 56.9%,47.9%至 66.3%)。

结论

在分娩开始时接受初级保健的低危女性中,计划在家分娩的女性严重急性产妇发病率、产后出血和人工胎盘剥离率低于计划在医院分娩的女性。对于经产妇,这些差异具有统计学意义。两组的绝对风险均较小。在具有训练有素的助产士和良好的转诊和运输系统的产妇保健系统中,没有证据表明低危女性在家中分娩会导致严重不良产妇结局的风险增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96c8/4790763/b2a3ee733230/deja010923.f1_default.jpg

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