工程化外周神经修复。
Engineering peripheral nerve repair.
机构信息
Department of Biomedical Engineering, Washington University, St. Louis, MO 63130, USA.
出版信息
Curr Opin Biotechnol. 2013 Oct;24(5):887-92. doi: 10.1016/j.copbio.2013.05.006. Epub 2013 Jun 19.
Abstract
Current approaches for treating peripheral nerve injury have resulted in promising, yet insufficient functional recovery compared to the clinical standard of care, autologous nerve grafts. In order to design a construct that can match the regenerative potential of the autograft, all facets of nerve tissue must be incorporated in a combinatorial therapy. Engineered biomaterial scaffolds in the future will have to promote enhanced regeneration and appropriate reinnervation by targeting the highly sensitive response of regenerating nerves to their surrounding microenvironment.
摘要
目前治疗周围神经损伤的方法与自体神经移植的临床标准相比，取得了有希望但仍不充分的功能恢复。为了设计一种可以与自体移植物的再生潜力相匹配的构建体，必须将神经组织的各个方面纳入组合治疗中。未来的工程生物材料支架将通过针对再生神经对其周围微环境的高度敏感反应，促进增强的再生和适当的再神经支配。
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本文引用的文献
1
Comparison of neurite growth in three dimensional natural and synthetic hydrogels.三维天然和合成水凝胶中神经突生长的比较。
J Biomater Sci Polym Ed. 2013;24(3):301-14. doi: 10.1080/09205063.2012.690277. Epub 2012 Aug 13.
2
Design of three-dimensional engineered protein hydrogels for tailored control of neurite growth.设计三维工程化蛋白水凝胶以实现对神经突生长的定制化控制。
Acta Biomater. 2013 Mar;9(3):5590-9. doi: 10.1016/j.actbio.2012.10.033. Epub 2012 Nov 2.
3
Induction of rat facial nerve regeneration by functional collagen scaffolds.功能性胶原支架诱导大鼠面神经再生。
Biomaterials. 2013 Jan;34(4):1302-10. doi: 10.1016/j.biomaterials.2012.10.031. Epub 2012 Oct 31.
4
Functional recovery guided by an electrospun silk fibroin conduit after sciatic nerve injury in rats.大鼠坐骨神经损伤后电纺丝素蛋白导管引导下的功能恢复
J Tissue Eng Regen Med. 2015 Jan;9(1):66-76. doi: 10.1002/term.1615. Epub 2012 Oct 22.
5
End-to-side neurorrhaphy using an electrospun PCL/collagen nerve conduit for complex peripheral motor nerve regeneration.采用静电纺丝 PCL/胶原神经导管的端侧神经吻合术促进复杂周围运动神经再生。
Biomaterials. 2012 Dec;33(35):9027-36. doi: 10.1016/j.biomaterials.2012.09.008. Epub 2012 Sep 19.
6
Effect of surface pore structure of nerve guide conduit on peripheral nerve regeneration.神经导管表面孔结构对周围神经再生的影响。
Tissue Eng Part C Methods. 2013 Mar;19(3):233-43. doi: 10.1089/ten.TEC.2012.0221. Epub 2012 Sep 13.
7
The effect of intraluminal contact mediated guidance signals on axonal mismatch during peripheral nerve repair.管腔内接触介导的导向信号对周围神经修复过程中轴突失配的影响。
Biomaterials. 2012 Oct;33(28):6660-71. doi: 10.1016/j.biomaterials.2012.06.002. Epub 2012 Jun 25.
8
Electrical stimulation to conductive scaffold promotes axonal regeneration and remyelination in a rat model of large nerve defect.电刺激导电支架促进大鼠大神经缺损模型中的轴突再生和髓鞘再生。
PLoS One. 2012;7(6):e39526. doi: 10.1371/journal.pone.0039526. Epub 2012 Jun 21.
9
The impact of laminin on 3D neurite extension in collagen gels.层粘连蛋白对胶原凝胶中 3D 神经突延伸的影响。
J Neural Eng. 2012 Aug;9(4):046007. doi: 10.1088/1741-2560/9/4/046007. Epub 2012 Jun 27.
10
Microtissue engineered constructs with living axons for targeted nervous system reconstruction.用于靶向神经系统重建的具有活轴突的微组织工程构建体。
Tissue Eng Part A. 2012 Nov;18(21-22):2280-9. doi: 10.1089/ten.TEA.2011.0534. Epub 2012 Aug 17.
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