工程化外周神经修复。
Engineering peripheral nerve repair.
机构信息
Department of Biomedical Engineering, Washington University, St. Louis, MO 63130, USA.
出版信息
Curr Opin Biotechnol. 2013 Oct;24(5):887-92. doi: 10.1016/j.copbio.2013.05.006. Epub 2013 Jun 19.
Abstract
Current approaches for treating peripheral nerve injury have resulted in promising, yet insufficient functional recovery compared to the clinical standard of care, autologous nerve grafts. In order to design a construct that can match the regenerative potential of the autograft, all facets of nerve tissue must be incorporated in a combinatorial therapy. Engineered biomaterial scaffolds in the future will have to promote enhanced regeneration and appropriate reinnervation by targeting the highly sensitive response of regenerating nerves to their surrounding microenvironment.
摘要
目前治疗周围神经损伤的方法与自体神经移植的临床标准相比，取得了有希望但仍不充分的功能恢复。为了设计一种可以与自体移植物的再生潜力相匹配的构建体，必须将神经组织的各个方面纳入组合治疗中。未来的工程生物材料支架将通过针对再生神经对其周围微环境的高度敏感反应，促进增强的再生和适当的再神经支配。
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本文引用的文献
1
Comparison of neurite growth in three dimensional natural and synthetic hydrogels.
J Biomater Sci Polym Ed. 2013;24(3):301-14. doi: 10.1080/09205063.2012.690277. Epub 2012 Aug 13.
2
Design of three-dimensional engineered protein hydrogels for tailored control of neurite growth.
Acta Biomater. 2013 Mar;9(3):5590-9. doi: 10.1016/j.actbio.2012.10.033. Epub 2012 Nov 2.
3
Induction of rat facial nerve regeneration by functional collagen scaffolds.
Biomaterials. 2013 Jan;34(4):1302-10. doi: 10.1016/j.biomaterials.2012.10.031. Epub 2012 Oct 31.
4
Functional recovery guided by an electrospun silk fibroin conduit after sciatic nerve injury in rats.
J Tissue Eng Regen Med. 2015 Jan;9(1):66-76. doi: 10.1002/term.1615. Epub 2012 Oct 22.
5
End-to-side neurorrhaphy using an electrospun PCL/collagen nerve conduit for complex peripheral motor nerve regeneration.
Biomaterials. 2012 Dec;33(35):9027-36. doi: 10.1016/j.biomaterials.2012.09.008. Epub 2012 Sep 19.
6
Effect of surface pore structure of nerve guide conduit on peripheral nerve regeneration.
Tissue Eng Part C Methods. 2013 Mar;19(3):233-43. doi: 10.1089/ten.TEC.2012.0221. Epub 2012 Sep 13.
7
The effect of intraluminal contact mediated guidance signals on axonal mismatch during peripheral nerve repair.
Biomaterials. 2012 Oct;33(28):6660-71. doi: 10.1016/j.biomaterials.2012.06.002. Epub 2012 Jun 25.
8
Electrical stimulation to conductive scaffold promotes axonal regeneration and remyelination in a rat model of large nerve defect.
PLoS One. 2012;7(6):e39526. doi: 10.1371/journal.pone.0039526. Epub 2012 Jun 21.
9
The impact of laminin on 3D neurite extension in collagen gels.
J Neural Eng. 2012 Aug;9(4):046007. doi: 10.1088/1741-2560/9/4/046007. Epub 2012 Jun 27.
10
Microtissue engineered constructs with living axons for targeted nervous system reconstruction.
Tissue Eng Part A. 2012 Nov;18(21-22):2280-9. doi: 10.1089/ten.TEA.2011.0534. Epub 2012 Aug 17.
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