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Antimicrobial effect of chlorhexidine digluconate in dentin: In vitro and in situ study.葡萄糖酸氯己定在牙本质中的抗菌作用：体外和原位研究。
J Conserv Dent. 2012 Jan;15(1):22-6. doi: 10.4103/0972-0707.92601.
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Dentinal tubule disinfection with 2% chlorhexidine gel, propolis, morinda citrifolia juice, 2% povidone iodine, and calcium hydroxide.用 2%洗必泰凝胶、蜂胶、桑椹汁、2%聚维酮碘和氢氧化钙对牙本质小管进行消毒。
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J Endod. 2007 Dec;33(12):1473-6. doi: 10.1016/j.joen.2007.08.016.
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Detection and quantitation of E. faecalis by real-time PCR (qPCR), reverse transcription-PCR (RT-PCR), and cultivation during endodontic treatment.在牙髓治疗期间，通过实时聚合酶链反应（qPCR）、逆转录聚合酶链反应（RT-PCR）和培养法对粪肠球菌进行检测和定量分析。
J Endod. 2006 Aug;32(8):715-21. doi: 10.1016/j.joen.2006.02.031. Epub 2006 Jun 6.
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Enterococcus faecalis-mediated biomineralized biofilm formation on root canal dentine in vitro.粪肠球菌介导的根管牙本质体外生物矿化生物膜形成
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使用实时聚合酶链反应研究2%氯己定、大蒜提取物和氢氧化钙对粪肠球菌进行牙本质小管消毒的体外研究

Dentinal tubule disinfection with 2% chlorhexidine, garlic extract, and calcium hydroxide against Enterococcus faecalis by using real-time polymerase chain reaction: In vitro study.

作者信息

Eswar Kandaswamy, Venkateshbabu Nagendrababu, Rajeswari Kalaiselvam, Kandaswamy Deivanayagam

机构信息

Department of Conservative Dentistry and Endodontics, Faculty of Dental Sciences, Sri Ramachandra University, Chennai, Tamil Nadu, India.

出版信息

J Conserv Dent. 2013 May;16(3):194-8. doi: 10.4103/0972-0707.111312.

DOI:10.4103/0972-0707.111312
PMID:23833449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3698579/
Abstract

AIM

To compare the efficacy of garlic extract with 2% chlorhexidine (CHX) and calcium hydroxide Ca(OH)2 in disinfection of dentinal tubules contaminated with Enterococcus faecalis by using real-time polymerase chain reaction (PCR).

MATERIALS AND METHODS

Agar diffusion test was done to evaluate the minimum inhibitory concentration of garlic extract against E. faecalis. Forty human extracted mandibular premolar teeth were selected for this study, access cavity was prepared and cleaning and shaping was done. Middle third of the root was cut using a rotary diamond disc. The teeth specimens were inoculated with E. faecalis for 21 days. Specimens were divided into four groups---Group 1: 2% CHX, Group 2: Garlic extract, Group 3: Ca(OH)2, and Group 4: Saline (negative control). The intracanal medicaments were packed inside the tooth specimens and incubated for 5 days. The dentinal chips were collected at 400 μm depth using a Gates-Glidden drill, following which DNA isolation was done. The specimens were analyzed using real-time PCR. The results were then statistically analyzed using one-way analysis of variance, followed by post hoc Tukey's honestly significant difference (HSD) multiple comparison of means.

RESULTS

Threshold cycle (Ct) values of 2% CHX was found to be 32.4, garlic extract to be 27.5, and Ca(OH)2 to be 25.6.

CONCLUSION

A total of 2% CHX showed the maximum efficacy against E. faecalis, followed by garlic extract and Ca(OH)2.

摘要

目的

通过实时聚合酶链反应（PCR）比较大蒜提取物与2%氯己定（CHX）和氢氧化钙Ca(OH)₂对粪肠球菌污染的牙本质小管的消毒效果。

材料与方法

采用琼脂扩散试验评估大蒜提取物对粪肠球菌的最低抑菌浓度。本研究选取40颗拔除的人类下颌前磨牙，制备进入腔并进行清洁和成形。使用旋转金刚石盘切割牙根的中三分之一。将牙齿标本接种粪肠球菌21天。标本分为四组——第1组：2% CHX，第2组：大蒜提取物，第3组：Ca(OH)₂，第4组：生理盐水（阴性对照）。将根管内药物填充到牙齿标本中并孵育5天。使用盖茨-格利登钻在400μm深度收集牙本质碎屑，随后进行DNA提取。使用实时PCR对标本进行分析。然后使用单因素方差分析对结果进行统计学分析，随后进行事后Tukey真实显著差异（HSD）均值多重比较。

结果

发现2% CHX的阈值循环（Ct）值为32.4，大蒜提取物为27.5，Ca(OH)₂为25.6。

结论

总体而言，2% CHX对粪肠球菌的消毒效果最佳，其次是大蒜提取物和Ca(OH)₂。