Department of Biochemistry, National Root Crops Research Institute, P.O. Box 380, Umuahia, Abia State, Nigeria.
J Diabetes Res. 2013;2013:160964. doi: 10.1155/2013/160964. Epub 2013 Jul 22.
To investigate the ameliorating potentials of cocoyam (Colocasia esculenta L.) and unripe plantain (Musa paradisiaca L.) incorporated feeds on the renal and liver growths of diabetic rats, induced with 55 and 65 mg/kg body weight of Streptozotocin.
The blood glucose level of the rats was measured with a glucometer, the protein and glucose and specific gravity (SPGR) in the urine samples of the rats were measured using urine assay strips and urinometer respectively. The chemical composition and antioxidant screening of the test feeds were carried out using standard techniques.
Administration of the test feeds for 21 days to the diabetic rats of groups 4 and 5, resulted in 58.75% and 38.13% decreases in hyperglycemia and amelioration of their elevated urinary protein, glucose, SPGR, and relative kidney weights. The diabetic rats administered cocoyam incorporated feeds, had 2.71% and 19.52% increases in weight and growth rates, the diabetic rats administered unripe plantain incorporated feeds had 5.12% and 29.52% decreases in weight and growth rates while the diabetic control rats had 28.69%, 29.46%, 248.9% and 250.14% decreases in weights and growth rates. The cocoyam incorporated feeds contained higher antioxidants, minerals and phytochemicals except alkaloids than unripe plantain feed.
Cocoyam and unripe plantain could be useful in the management of diabetic nephropathy.
研究芋（Colocasia esculenta L.）和生芭蕉（Musa paradisiaca L.）掺入饲料对 55 和 65mg/kg 体重链脲佐菌素诱导的糖尿病大鼠肾脏和肝脏生长的改善作用。
使用血糖仪测量大鼠的血糖水平，使用尿液分析条和尿比重计分别测量大鼠尿液中的蛋白质、葡萄糖和比重（SPGR）。使用标准技术对测试饲料的化学成分和抗氧化筛选进行了分析。
在第 4 组和第 5 组糖尿病大鼠中，连续 21 天给予测试饲料，可使高血糖降低 58.75%和 38.13%，并改善其升高的尿蛋白、葡萄糖、SPGR 和相对肾脏重量。给予芋掺入饲料的糖尿病大鼠体重和生长速度分别增加了 2.71%和 19.52%，给予生芭蕉掺入饲料的糖尿病大鼠体重和生长速度分别降低了 5.12%和 29.52%，而糖尿病对照组大鼠的体重和生长速度分别降低了 28.69%、29.46%、248.9%和 250.14%。芋掺入饲料中的抗氧化剂、矿物质和植物化学物质含量高于生芭蕉饲料，除生物碱外。
芋和生芭蕉可能有助于糖尿病肾病的管理。
