Camci-Unal Gulden, Alemdar Neslihan, Annabi Nasim, Khademhosseini Ali
Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA ; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.
Polym Int. 2013 Jun 1;62(6):843-848. doi: 10.1002/pi.4502.
Due to the increasing demand to generate thick and vascularized tissue engineered constructs, novel strategies are currently being developed. An emerging example is the generation of oxygen-releasing biomaterials to tackle mass transport and diffusion limitations within engineered tissue-like constructs. Biomaterials containing oxygen releasing molecules can be fabricated in various forms such as, hybrid thin films, microparticles, or three dimensional (3D) scaffolds. In this perspective, we will summarize various oxygen-releasing reagents and their potential applications in regenerative engineering. Moreover, we will review the main approaches to fabricate oxygen-releasing biomaterials for a range of tissue engineering applications.
由于生成厚且具有血管化的组织工程构建体的需求不断增加，目前正在开发新的策略。一个新出现的例子是生成氧释放生物材料，以解决工程化组织样构建体内的传质和扩散限制问题。含有氧释放分子的生物材料可以制成各种形式，如混合薄膜、微粒或三维（3D）支架。从这个角度出发，我们将总结各种氧释放试剂及其在再生工程中的潜在应用。此外，我们将回顾为一系列组织工程应用制造氧释放生物材料的主要方法。
