Life Science Department, University of Trieste, via Giorgieri 1, I-34127 Trieste, Italy.
Adv Drug Deliv Rev. 2013 Dec;65(15):2034-44. doi: 10.1016/j.addr.2013.07.002. Epub 2013 Jul 13.
In the last decade, we have experienced an increasing interest and an improved understanding of the application of nanotechnology to the nervous system. The aim of such studies is that of developing future strategies for tissue repair to promote functional recovery after brain damage. In this framework, carbon nanotube based technologies are emerging as particularly innovative tools due to the outstanding physical properties of these nanomaterials together with their recently documented ability to interface neuronal circuits, synapses and membranes. This review will discuss the state of the art in carbon nanotube technology applied to the development of devices able to drive nerve tissue repair; we will highlight the most exciting findings addressing the impact of carbon nanotubes in nerve tissue engineering, focusing in particular on neuronal differentiation, growth and network reconstruction.
在过去的十年中，我们对纳米技术在神经系统中的应用越来越感兴趣，也有了更深入的理解。这些研究的目的是开发未来的组织修复策略，以促进脑损伤后的功能恢复。在这一框架下，基于碳纳米管的技术由于这些纳米材料的出色物理性能以及它们最近被证明能够与神经元回路、突触和膜相互作用，正在成为一种特别有创新性的工具。这篇综述将讨论将碳纳米管技术应用于开发能够驱动神经组织修复的器件的最新进展；我们将重点介绍最令人兴奋的发现，这些发现涉及碳纳米管在神经组织工程中的影响，特别是神经元分化、生长和网络重建。
