Medizinische Klinik 1, Universitätsklinikum Erlangen, Ulmenweg 18, D-91054 Erlangen, Germany.
Nat Rev Gastroenterol Hepatol. 2013 Dec;10(12):704-12. doi: 10.1038/nrgastro.2013.125. Epub 2013 Jul 16.
Molecular imaging is a novel field in gastroenterology that uses fluorescently labelled probes to specifically highlight neoplastic lesions on the basis of their molecular signature. The development of molecular imaging has been driven by the need to improve endoscopic diagnosis and by progress in targeted therapies in gastrointestinal oncology to provide individualized treatment, which coincides with progress in endoscopy techniques and further miniaturization of detection devices. Different exogenous molecular probes for imaging include labelled antibodies, oligopeptides, affibodies(™) (Affibody AB, Bromma, Sweden), aptamers and activatable probes. Molecular imaging has been evaluated in two major indications: many trials have studied molecular imaging as a red flag technique to improve detection of lesions in wide-field imaging; on the other hand, microscopic analysis has been investigated for in vivo characterization of the molecular fingerprint of tumours with the ultimate goal of assessing the likelihood of response to targeted therapy. This Review focusses on the applications of molecular imaging that have immediate potential for translational science or imminent transition into clinical practice of gastrointestinal endoscopy.
分子影像学是消化内科的一个新兴领域，它使用荧光标记探针根据肿瘤的分子特征特异性地突出显示肿瘤病变。分子影像学的发展是由提高内镜诊断的需要以及胃肠道肿瘤靶向治疗的进展所驱动的，这些进展为提供个体化治疗提供了可能，而这与内镜技术的进步和检测设备的进一步微型化是一致的。用于成像的不同外源性分子探针包括标记抗体、寡肽、亲和体（Affibody AB，Bromma，瑞典）、适体和可激活探针。分子影像学已经在两个主要适应证中进行了评估：许多试验已经研究了分子影像学作为一种红旗技术，以提高在宽视场成像中检测病变的能力；另一方面，已经研究了微观分析用于体内肿瘤分子指纹特征的描述，最终目的是评估对靶向治疗反应的可能性。这篇综述重点介绍了分子影像学的应用，这些应用具有转化科学的直接潜力，或者即将过渡到胃肠道内镜的临床实践。
