El-Tantawy Walid Hamdy
National Organization for Drug Control & Research, Cairo, Egypt,
J Physiol Biochem. 2014 Mar;70(1):33-42. doi: 10.1007/s13105-013-0277-0. Epub 2013 Jul 20.
Cardiovascular diseases (CVDs) are the major health problem of advanced as well as developing countries of the world. The aim of the present study was to investigate the protective effect of the Solidago virgaurea extract on isoproterenol-induced cardiotoxicity in rats. The subcutaneous injection of isoproterenol (30 mg/kg) into rats twice at an interval of 24 h, for two consecutive days, led to a significant increase in serum lactate dehydrogenase, creatine phosphokinase, alanine transaminase, aspartate transaminase, and angiotensin-converting enzyme activities, total cholesterol, triglycerides, free serum fatty acid, cardiac tissue malondialdehyde (MDA), and nitric oxide levels and a significant decrease in levels of glutathione and superoxide dismutase in cardiac tissue as compared to the normal control group (P < 0.05). Pretreatment with S. virgaurea extract for 5 weeks at a dose of 250 mg/kg followed by isoproterenol injection significantly prevented the observed alterations. Captopril (50 mg/kg/day, given orally), an inhibitor of angiotensin-converting enzyme used as a standard cardioprotective drug, was used as a positive control in this study. The data of the present study suggest that S. virgaurea extract exerts its protective effect by decreasing MDA level and increasing the antioxidant status in isoproterenol-treated rats. The study emphasizes the beneficial action of S. virgaurea extract as a cardioprotective agent.
心血管疾病是世界上发达国家和发展中国家的主要健康问题。本研究的目的是探讨一枝黄花提取物对异丙肾上腺素诱导的大鼠心脏毒性的保护作用。连续两天，每隔24小时给大鼠皮下注射异丙肾上腺素（30毫克/千克），导致血清乳酸脱氢酶、肌酸磷酸激酶、丙氨酸转氨酶、天冬氨酸转氨酶和血管紧张素转换酶活性、总胆固醇、甘油三酯、游离血清脂肪酸、心脏组织丙二醛（MDA）和一氧化氮水平显著升高，与正常对照组相比，心脏组织中谷胱甘肽和超氧化物歧化酶水平显著降低（P < 0.05）。以250毫克/千克的剂量用一枝黄花提取物预处理5周，然后注射异丙肾上腺素，显著预防了观察到的变化。在本研究中，作为标准心脏保护药物的血管紧张素转换酶抑制剂卡托普利（50毫克/千克/天，口服）用作阳性对照。本研究数据表明，一枝黄花提取物通过降低异丙肾上腺素处理的大鼠的MDA水平和提高抗氧化状态发挥其保护作用。该研究强调了一枝黄花提取物作为心脏保护剂的有益作用。
