College of Chemistry and Biological Science, Yili Normal University, Yining, Xinjiang 835000, China ; Department of Biology, School of Life Science, Sun Yat-sen University, Guangzhou 510275, China.
Evid Based Complement Alternat Med. 2013;2013:783860. doi: 10.1155/2013/783860. Epub 2013 Jul 9.
Recent studies suggested that green tea has the potential to protect against diet-induced obesity. The presence of caffeine within green tea has caused limitations. Cocoa tea (Camellia ptilophylla) is a naturally decaffeinated tea plant. To determine whether cocoa tea supplementation results in an improvement in high-fat diet-induced obesity, hyperlipidemia and hepatic steatosis, and whether such effects would be comparable to those of green tea extract, we studied six groups (n = 10) of C57BL/6 mice that were fed with (1) normal chow (N); (2) high-fat diet (21% butterfat + 0.15% cholesterol, wt/wt) (HF); (3) a high-fat diet supplemented with 2% green tea extract (HFLG); (4) a high-fat diet supplemented with 4% green tea extract (HFHG); (5) a high-fat diet supplemented with 2% cocoa tea extract (HFLC); and (6) a high-fat diet supplemented with 4% cocoa tea extract (HFHC). From the results, 2% and 4% dietary cocoa tea supplementation caused a dose-dependent decrease in (a) body weight, (b) fat pad mass, (c) liver weight, (d) total liver lipid, (e) liver triglyceride and cholesterol, and (f) plasma lipids (triglyceride and cholesterol). These data indicate that dietary cocoa tea, being naturally decaffeinated, has a beneficial effect on high-fat diet-induced obesity, hepatomegaly, hepatic steatosis, and elevated plasma lipid levels in mice, which are comparable to green tea. The present findings have provided the proof of concept that dietary cocoa tea might be of therapeutic value and could therefore provide a safer and cost effective option for patients with diet-induced metabolic syndrome.
最近的研究表明，绿茶具有预防饮食诱导肥胖的潜力。绿茶中咖啡因的存在带来了一些限制。可可茶（Camellia ptilophylla）是一种天然无咖啡因的茶树种。为了确定可可茶补充剂是否能改善高脂肪饮食诱导的肥胖、高血脂和肝脂肪变性，以及这些效果是否与绿茶提取物相当，我们研究了六组（n = 10）C57BL/6 小鼠，它们分别喂食：（1）普通饲料（N）；（2）高脂肪饮食（21%黄油脂肪+0.15%胆固醇，wt/wt）（HF）；（3）高脂肪饮食补充 2%绿茶提取物（HFLG）；（4）高脂肪饮食补充 4%绿茶提取物（HFHG）；（5）高脂肪饮食补充 2%可可茶提取物（HFLC）；和（6）高脂肪饮食补充 4%可可茶提取物（HFHC）。结果显示，2%和 4%的可可茶饮食补充剂量依赖性地降低了（a）体重、（b）脂肪垫质量、（c）肝重、（d）总肝脂质、（e）肝甘油三酯和胆固醇，以及（f）血浆脂质（甘油三酯和胆固醇）。这些数据表明，可可茶作为一种天然无咖啡因的饮品，对高脂肪饮食诱导的肥胖、肝肿大、肝脂肪变性和血浆脂质水平升高具有有益作用，与绿茶相当。本研究结果提供了概念验证，即可可茶可能具有治疗价值，因此为饮食诱导的代谢综合征患者提供了一种更安全、更具成本效益的选择。
