Health & Disease Research Center for Rural Peoples (HDRCRP), 14/15, Probal Housing Ltd., Mohammadpur, Dhaka, Bangladesh.
PLoS One. 2013 Aug 2;8(8):e68319. doi: 10.1371/journal.pone.0068319. Print 2013.
Parity increases the risk for coronary heart disease; however, its association with metabolic syndrome among women in low-income countries is still unknown.
This study investigates the association between parity or gravidity and metabolic syndrome in rural Bangladeshi women.
A cross-sectional study was conducted in 1,219 women aged 15-75 years from rural Bangladesh. Metabolic syndrome was defined according to the standard NCEP-ATP III criteria. Logistic regression was used to estimate the association between parity and gravidity and metabolic syndrome, with adjustment of potential confounding variables.
Subjects with the highest gravidity (> = 4) had 1.66 times higher odds of having metabolic syndrome compared to those in the lowest gravidity (0-1) (P trend = 0.02). A similar association was found between parity and metabolic syndrome (P(trend) = 0.04), i.e., subjects in the highest parity (> = 4) had 1.65 times higher odds of having metabolic syndrome compared to those in the lowest parity (0-1). This positive association of parity and gravidity with metabolic syndrome was confined to pre-menopausal women (P(trend) <0.01). Among the components of metabolic syndrome only high blood pressure showed positive association with parity and gravidity (P(trend) = 0.01 and <0.001). Neither Parity nor gravidity was appreciably associated with other components of metabolic syndrome.
Multi parity or gravidity may be a risk factor for metabolic syndrome.
生育子女会增加患冠心病的风险；然而，在低收入国家，生育子女与女性代谢综合征之间的关系尚不清楚。
本研究旨在调查生育子女的数量与孟加拉国农村女性代谢综合征之间的关系。
本横断面研究纳入了来自孟加拉国农村地区的 1219 名年龄在 15-75 岁之间的女性。代谢综合征按照 NCEP-ATP III 标准进行定义。采用 logistic 回归来估计生育子女的数量与代谢综合征之间的关联，并对潜在的混杂因素进行调整。
与生育子女数量最低（0-1）的女性相比，生育子女数量最高（>=4）的女性患代谢综合征的几率高出 1.66 倍（P 趋势=0.02）。生育子女的数量与代谢综合征之间也存在类似的关联（P 趋势=0.04），即生育子女数量最高（>=4）的女性患代谢综合征的几率高出 1.65 倍（P 趋势=0.04）。这种生育子女的数量与代谢综合征之间的正相关关系仅局限于绝经前女性（P 趋势<0.01）。在代谢综合征的各个组分中，只有高血压与生育子女的数量呈正相关（P 趋势=0.01 和<0.001）。生育子女的数量与代谢综合征的其他组分没有明显关联。
多胎生育可能是代谢综合征的一个危险因素。
