Voiosu Theodor Alexandru, Giurcan Roxana, Voiosu Andrei Mihai, Voiosu Mihail Radu
Department of Gastroenterology, Colentina Clinical Hospital, Bucharest, Romania ; "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Maedica (Bucur). 2013 Mar;8(1):68-74.
Functional dyspepsia (FD) is a disorder presenting with symptoms such as postprandial fullness, early satiety or epigastric pain. Although there is a 10 to 30% reported prevalence worldwide, there is currently no clear explanation of the pathophysiology behind this condition. Motility disorders, visceral hypersensitivity, acid disorders, Helicobacter pylori infection or psychosocial factors have all been reported to play a part in the pathophysiology of FD. The diagnosis of FD is one of exclusion, based on the Rome III criteria. The main therapeutic modalities include lifestyle changes, eradicating Helicobacter pylori infection and treatment with either proton pump inhibitors, prokinetics or antidepressants.
功能性消化不良（FD）是一种以餐后饱胀、早饱或上腹部疼痛等症状为表现的疾病。尽管全球报道的患病率为10%至30%，但目前对于该病症背后的病理生理学尚无明确解释。据报道，运动障碍、内脏高敏感性、酸紊乱、幽门螺杆菌感染或心理社会因素在FD的病理生理学中均发挥作用。FD的诊断是基于罗马Ⅲ标准的排除性诊断。主要治疗方式包括生活方式改变、根除幽门螺杆菌感染以及使用质子泵抑制剂、促动力药或抗抑郁药进行治疗。
