Pacific Center for Emerging Infectious Diseases Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA.
Taup'green France, BP 19 92201, Neuilly sur Seine, France.
Epidemiol Infect. 2014 Jun;142(6):1167-71. doi: 10.1017/S0950268813002197. Epub 2013 Sep 18.
Recent discovery of genetically distinct hantaviruses in shrews and moles (order Soricomorpha, family Soricidae and Talpidae) has challenged the conventional view that rodents serve as the principal reservoir hosts. Nova virus (NVAV), previously identified in archival liver tissue of a single European mole (Talpa europaea) from Hungary, represents one of the most highly divergent hantaviruses identified to date. To ascertain the spatial distribution and genetic diversity of NVAV, we employed RT-PCR to analyse lungs from 94 moles, captured in two locations in France, during October 2012 to March 2013. NVAV was detected in more than 60% of moles at each location, suggesting efficient enzootic virus transmission and confirming that this mole species serves as the reservoir host. Although the pathogenic potential of NVAV is unknown, the widespread geographical distribution of the European mole might pose a hantavirus exposure risk for humans.
最近在鼩鼱和鼹鼠（食虫目，鼩鼱科和鼹科）中发现了遗传上不同的汉坦病毒，这挑战了啮齿动物作为主要储存宿主的传统观点。新型病毒（NVAV）以前在来自匈牙利的单个欧洲鼹（Talpa europaea）的存档肝组织中被发现，是迄今为止鉴定出的高度分化的汉坦病毒之一。为了确定 NVAV 的空间分布和遗传多样性，我们使用 RT-PCR 分析了 2012 年 10 月至 2013 年 3 月期间在法国两个地点捕获的 94 只鼹鼠的肺部。在每个地点，NVAV 都在超过 60%的鼹鼠中被检测到，这表明有效的地方性病毒传播，并证实这种鼹鼠物种是储存宿主。尽管 NVAV 的致病潜力尚不清楚，但欧洲鼹鼠广泛的地理分布可能对人类构成汉坦病毒暴露风险。
