Chung Tae-Ho, Kim Hee-Dong, Lee Young-Sun, Hwang Cheol-Yong
Department of Companion Animal and Animal Resources Science, Joongbu University, 1 Daehak-ro, Chubu-myeon, Geumsan-gun, Chungnam 312-702 South Korea.
J Vet Med Sci. 2014 Jan;76(1):73-9. doi: 10.1292/jvms.13-0223. Epub 2013 Sep 20.
Helicobacter spp. may have multiple routes of transmission. It is unclear, however, whether the agent is zoonotic and therefore transmitted from an animal reservoir, including dogs. The aim of this population-based study was to assess the relationship between pet ownership or frequent exposure to dogs and Helicobacter spp. infection, especially focusing on HHLO-2 (Helicobacter heilmannii-like organisms type 2) in saliva and feces samples in Korea, using non-invasive genus/species-specific PCR. One hundred twenty-four eligible human subjects and 39 dogs participated in this study. Relativity of contact with dogs and Helicobacter spp. infection diagnosed by genus-specific PCR showed a statistically significant result (P<0.01), but in the relativity analyses between contact with dogs and H. pylori, H. felis and H. bizzozeronii infections diagnosed using species-specific PCR, only Helicobacter felis showed a statistically significant result. Although H. pylori infection showed a statistically significant relativity, no statistically significant association was found between veterinarian subjects and Helicobacter. spp., H. felis and H. bizzozeronii infections. On performing risk factor analyses of HHLO-2 infection by transmission, using matching species, between HHLO-2-positive dog owners and HHLO-2-positive dogs, Helicobacter felis infection showed an extremely significant relativity (P<0.0001), and Helicobacter bizzozeronii may also be a possible significant risk factor (P<0.01). These results suggest that HHLO-2 infection might be a zoonotic infection, because continuous contact with dogs was proved to be correlated with human H. felis and H. bizzozeronii infections in this study.
幽门螺杆菌属可能有多种传播途径。然而，尚不清楚该病原体是否为人畜共患病原体，因此是否从包括狗在内的动物宿主传播。这项基于人群的研究旨在评估养宠物或经常接触狗与幽门螺杆菌属感染之间的关系，特别是使用非侵入性属/种特异性聚合酶链反应（PCR），重点研究韩国唾液和粪便样本中的HHLO-2（2型海氏螺杆菌样生物）。124名符合条件的人类受试者和39只狗参与了这项研究。通过属特异性PCR诊断的与狗接触和幽门螺杆菌属感染之间的相关性显示出具有统计学意义的结果（P<0.01），但在使用种特异性PCR诊断的与狗接触和幽门螺杆菌、猫螺杆菌和比氏螺杆菌感染之间的相关性分析中，只有猫螺杆菌显示出具有统计学意义的结果。尽管幽门螺杆菌感染显示出具有统计学意义的相关性，但在兽医受试者与幽门螺杆菌属、猫螺杆菌和比氏螺杆菌感染之间未发现具有统计学意义的关联。在通过匹配物种对HHLO-2感染的传播进行风险因素分析时，在HHLO-2阳性狗主人和HHLO-2阳性狗之间，猫螺杆菌感染显示出极其显著的相关性（P<0.0001），比氏螺杆菌也可能是一个可能的显著风险因素（P<0.01）。这些结果表明，HHLO-2感染可能是一种人畜共患病感染，因为在本研究中，与狗的持续接触被证明与人类猫螺杆菌和比氏螺杆菌感染相关。
