Copia is transcriptionally responsive to environmental stress.

Adult Drosophila subjected to a variety of environmental stresses that induce classic Drosophila heat shock response simultaneously exhibit a rapid and significant rise in copia homologous transcripts. Levels of Drosophila Adh (alcohol dehydrogenase gene) and 18s ribosomal RNA were unaffected by environmental stress. Copia's ability to be induced by stress is correlated with the presence of sequences homologous to the heat shock promoter consensus sequence which appear to be appropriately positioned within the element's long terminal repeat (LTR). Although the copia-like element 297 also contains homologous sequences within its LTR, they are atypically positioned relative to the element's transcription start site and are non-functional in that the 297 element was not stress inducible. Hence, the position of the consensus sequence relative to a gene's transcription start site may be a factor in stress inducibility.