Tholen Susanne, Klofat Katharina, Pan Cheng Rui, Schmaderer Christoph, Lutz Jens, Heemann Uwe, Baumann Marcus
Department of Nephrology, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany.
J Clin Hypertens (Greenwich). 2013 Nov;15(11):833-8. doi: 10.1111/jch.12198. Epub 2013 Sep 16.
Aortic pulse wave velocity (aPWV) is elevated in patients with chronic kidney disease (CKD) and predicts cardiovascular risk. However, the natural progression of arterial stiffness in these patients remains uncertain. Therefore, the main aim of this study was to investigate the development of aPWV and to identify potential factors associated with its progression. aPWV measurement was carried out in 70 CKD patients at baseline and after 12 months. Correlations to several variables, in particular annual glomerular filtration rate reduction and diabetes mellitus, were studied. In the cohort, aPWV significantly increased in 1 year by 1.1 m/s (P<.01). Dividing the group into patients with stable and progressive aPWV, factors associated with accelerated progression were age, systolic blood pressure, and diabetes, whereas loss of renal function had no significant impact. The annual aPWV progression in CKD patients reached 1 m/s, which predicts an increased cardiovascular risk. Variables involved with progressive arterial stiffness need further evaluation.
慢性肾脏病（CKD）患者的主动脉脉搏波速度（aPWV）升高，且可预测心血管风险。然而，这些患者动脉僵硬度的自然进展仍不确定。因此，本研究的主要目的是调查aPWV的发展情况，并确定与其进展相关的潜在因素。对70例CKD患者在基线时和12个月后进行了aPWV测量。研究了其与几个变量的相关性，特别是每年肾小球滤过率降低和糖尿病。在该队列中，aPWV在1年内显著增加了1.1 m/s（P<0.01）。将该组患者分为aPWV稳定和进展的患者，与加速进展相关的因素为年龄、收缩压和糖尿病，而肾功能丧失无显著影响。CKD患者的年aPWV进展达到1 m/s，这预示着心血管风险增加。与动脉僵硬度进展相关的变量需要进一步评估。
