Sireeratawong Seewaboon, Jaijoy Kanjana, Panunto Watcharin, Nanna Urarat, Lertprasertsuke Nirush, Soonthornchareonnon Noppamas
Division of Pharmacology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani 12120, Thailand.
Afr J Tradit Complement Altern Med. 2012 Dec 31;10(2):223-31. doi: 10.4314/ajtcam.v10i2.6. eCollection 2013.
Acute and chronic toxicities of the water extract from the dried fruits of Terminalia bellerica (Gaertn.) Roxb. were assessed in both female and male rats. For the study of acute toxicity, a single oral administration of the water extract at a dose of 5,000 mg/kg body weight (10 female, 10 male) was performed and the results showed no signs of toxicity such as general behavior changes, morbidity, mortality, changes on gross appearance or histopathological changes of the internal organs of rats. The study of chronic toxicity was determined by oral feeding both female and male rats (10 female, 10 male) daily with the test substance at the dose of 300, 600 and 1,200 mg/kg body weight continuously for 270 days. The examinations of signs of toxicity showed no abnormalities in the test groups compared to the controls. In addition, these rats were analyzed for final body and organ weights, necropsy, as well as hematological, blood chemical and histopathological parameters. Taken together, the water extract from the dried fruits of T. bellerica did not cause acute or chronic toxicities in either female or male rats.
对诃子（Terminalia bellerica (Gaertn.) Roxb.）干燥果实的水提取物在雌性和雄性大鼠中的急性和慢性毒性进行了评估。在急性毒性研究中，以5000毫克/千克体重的剂量对大鼠进行单次口服水提取物给药（10只雌性、10只雄性），结果显示未出现诸如一般行为变化、发病、死亡、大鼠外观变化或内脏组织病理学变化等毒性迹象。慢性毒性研究通过对雌性和雄性大鼠（10只雌性、10只雄性）每日口服剂量为300、600和1200毫克/千克体重的受试物质，持续270天来确定。毒性迹象检查显示，与对照组相比，试验组未出现异常。此外，对这些大鼠进行了终末体重和器官重量分析、尸检以及血液学、血液化学和组织病理学参数分析。综上所述，诃子干燥果实的水提取物在雌性或雄性大鼠中均未引起急性或慢性毒性。
