Département de médecine générale, UPMC Univ Paris 06, Paris, France ; UMRS 707, UPMC Univ Paris 06, Paris, France ; U707, INSERM, Paris, France.
PLoS One. 2013 Oct 25;8(10):e76020. doi: 10.1371/journal.pone.0076020. eCollection 2013.
Despite the fact that urinary tract infection (UTI) is a very frequent disease, little is known about its seasonality in the community.
To estimate seasonality of UTI using multiple time series constructed with available proxies of UTI. Eight time series based on two databases were used: sales of urinary antibacterial medications reported by a panel of pharmacy stores in France between 2000 and 2012, and search trends on the Google search engine for UTI-related terms between 2004 and 2012 in France, Germany, Italy, the USA, China, Australia and Brazil. Differences between summers and winters were statistically assessed with the Mann-Whitney test. We evaluated seasonality by applying the Harmonics Product Spectrum on Fast Fourier Transform. Seven time series out of eight displayed a significant increase in medication sales or web searches in the summer compared to the winter, ranging from 8% to 20%. The eight time series displayed a periodicity of one year. Annual increases were seen in the summer for UTI drug sales in France and Google searches in France, the USA, Germany, Italy, and China. Increases occurred in the austral summer for Google searches in Brazil and Australia.
An annual seasonality of UTIs was evidenced in seven different countries, with peaks during the summer.
尽管尿路感染 (UTI) 是一种非常常见的疾病，但人们对其在社区中的季节性知之甚少。
使用可用的 UTI 替代指标构建多个时间序列来估计 UTI 的季节性。使用了基于两个数据库的八个时间序列：2000 年至 2012 年间法国一组药店报告的尿路抗菌药物销售情况，以及 2004 年至 2012 年间法国、德国、意大利、美国、中国、澳大利亚和巴西在谷歌搜索引擎上搜索与 UTI 相关的术语的趋势。使用曼-惠特尼检验统计评估夏季和冬季之间的差异。我们通过在快速傅里叶变换上应用谐波乘积谱来评估季节性。八个时间序列中的七个显示了夏季药物销售或网络搜索明显高于冬季，幅度从 8%到 20%不等。八个时间序列显示出一年的周期性。法国的 UTI 药物销售和法国、美国、德国、意大利和中国的谷歌搜索在夏季呈逐年增长趋势。巴西和澳大利亚的谷歌搜索在澳大利亚夏季增加。
在七个不同的国家发现了 UTI 的季节性，夏季达到高峰。
