Department of Anesthesiology and Intensive Care School of Medicine, Medical University of Silesia in Katowice, Medyków 14, 40-752 Katowice, Poland.
Molecules. 2013 Nov 21;18(11):14397-413. doi: 10.3390/molecules181114397.
Medicines of biogenic origin with micro-organic, regenerative and analgesic properties are becoming more and more significant in the treatment of burn wounds. These properties are found in apitherapeutics such as propolis and honey--products collected and processed by a honey bee. Their effect on the course of the healing processes is multidirectional. The aim of the study was a histopathological and biochemical analysis of the processes of scar formation in experimentally evoked burn wounds in white pigs treated with the 1% and 3% Sepropol balms containing standardized extracts of propolis and honey. The results were compared with the therapeutic effects obtained with dermazin cream (1% silver sulfadiazine). The level of collagen was determined in the wounds treated with 1% and 3% Sepropol and compared with the collagen level in healthy skin and wounds treated with dermazin. Granulation and regenerated epithelium formation times were compared, with the 3% Sepropol being by far the most effective. The 3% Sepropol also increased the collagen level to 116% with the control sub-groups scoring between 80% and 98%. The results show the healing process of burn wounds in pigs treated with the Sepropol balm starts earlier and has a faster course than the standard dermazin therapy.
具有生物源、微生物、再生和镇痛特性的药物在烧伤治疗中的作用越来越重要。这些特性存在于蜂胶和蜂蜜等蜂产品中，这些产品是由蜜蜂采集和加工的。它们对愈合过程的影响是多方面的。本研究的目的是分析在白猪实验性烧伤伤口中，使用含有标准化蜂胶和蜂蜜提取物的 1%和 3%Sepropol 香脂治疗后，瘢痕形成过程的组织病理学和生化变化，并与 Dermazin 乳膏（1%磺胺嘧啶银）的治疗效果进行比较。在接受 1%和 3%Sepropol 治疗的伤口中测定了胶原蛋白的水平，并与健康皮肤和接受 Dermazin 治疗的伤口中的胶原蛋白水平进行了比较。比较了肉芽组织和再生上皮形成的时间，发现 3%Sepropol 的效果最为显著。3%Sepropol 还将胶原蛋白水平提高到 116%，而对照组的得分在 80%至 98%之间。结果表明，与标准的 Dermazin 治疗相比，用 Sepropol 香脂治疗的猪的烧伤伤口愈合过程开始得更早，进展得更快。
